垂体腺苷酸环化酶激活肽的研究概况
文献类型：期刊论文
| 作者 | 李喜龙[*]1; 赵兴绪2 |
| 刊名 | 生物化学与生物物理进展
 |
| 出版日期 | 2001 |
| 卷号 | 28期号:2页码:140-144 |
| 关键词 | 垂体腺苷酸环化酶激活肽 血管活性肠肽 受体 神经肽 |
| ISSN号 | 1000-3282 |
| 其他题名 | Pituitary adenylate cyclase-activating polypeptide |
| 通讯作者 | lixilong@hotmail.com |
| 合作状况 | 其它 |
| 中文摘要 | 垂体腺苷酸环化酶激活肽（PACAP ）及其受体存在于许多动物的下丘脑和垂体中，而且在肾上腺、睾丸、卵巢、肝脏、肾脏、 胰腺、松果腺、心脏、脊椎、神经节、呼吸系统和消化系统等组织或系统中也存在，其中肾 上腺含量最高.在这些组织或系统中，通过Ca2+、Na+、腺苷酸环化酶或磷酸肌醇等 作用通路，PACAP发挥神经递质/调质、或神经营养因子等生物学功能. |
| 英文摘要 | Pituitary adenylate cyclase-activating polypeptide (PACAP) which belongs to the secretin/glucagon/ VIP family has been originally isolated from the sheep hypothalamus on the basis of its ability to stimulate cAMP formation in culture rat anterior pituitary cells. Post-translational processing of the PACAP precursor generates two biologically active molecular forms, PACAP-38 and PACAP-27. The primary structure of PACAP has been remarkably conserved during evolution. The sequence of PACAP-27 exhibits substantial similarities with those of vasoactive intestinal polypeptide (VIP), glucagon and secretin. The gene encoding the PACAP precursor is widely expressed in brain and various peripheral organs, notably in endocrine glands, gastro-intestinal, urogenital tracts and respiratory system. In vivo, and in vitro studies have shown that PACAP exhibits multiple activities especially a trophic activity during ontogenesis, notably in the adrenal medulla and the central nervous system. The biological effects of PACAP are mediated through three distinct receptor subtypes which exhibit differential affinities for PACAP and VIP. The PAC1 receptor, which shows high selectivity for PACAP, is coupled to several transduction systems. In contrast, VPAC1 and VPAC2, which bind with the same affinity for PACAP and VIP, are mainly coupled to the adenylyl cyclase pathway. In conclusion, PACAP is neuropeptide, and it functions as a hypothalamic hormone, neurohormone, neuromodulator, vasodilator, neurotransmitter or trophic factor in the brain and the various organs. |
| 收录类别 | 其他 |
| 原文出处 | 2001282140.pdf |
| 语种 | 中文 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/3769]  |
| 专题 | 昆明动物研究所_生殖与发育生物学 |
| 作者单位 | 1.中国科学院昆明动物研究所,昆明650223 2.甘肃农业大学动物医学系,兰州730070 |
| 推荐引用方式 GB/T 7714 | 李喜龙[*],赵兴绪. 垂体腺苷酸环化酶激活肽的研究概况[J]. 生物化学与生物物理进展,2001,28(2):140-144. |
| APA | 李喜龙[*],&赵兴绪.(2001).垂体腺苷酸环化酶激活肽的研究概况.生物化学与生物物理进展,28(2),140-144. |
| MLA | 李喜龙[*],et al."垂体腺苷酸环化酶激活肽的研究概况".生物化学与生物物理进展 28.2(2001):140-144. |
入库方式： OAI收割
来源：昆明动物研究所
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