Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction
文献类型：期刊论文
| 作者 | Li XL; Su L[*] |
| 刊名 | VETERINARY RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2004 |
| 卷号 | 28期号:8页码:719-725 |
| 关键词 | endothelin-1 large intestinal obstruction nitric oxide synthase |
| ISSN号 | 0165-7380 |
| 通讯作者 | suleil@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Large intestinal obstruction (LIO) in farm animals can cause a ischaemic necrosis of intestinal tissue, eventually leading to death. The roles of endothelin-1 (ET-1) and nitric oxide (NO) are not well understood in the process of LIO, but evidence suggests that endothelial-derived mediators may participate. In the present study, ET-1 concentration and total nitric oxide synthase (NOS) activity were measured in heart, liver, pancreas, lung and kidney in a model of LIO in sheep. Our data demonstrated that ET-1 concentration and NOS activity were altered, with significant increases of ET-1 in heart, lung and kidney and of NOS activity in pancreas and kidney, but a marked decline of NOS activity in liver (p<0.05). It is postulated that these alterations in NOS activity and ET-1 concentration may contribute to the progressive loss of organ function, and finally lead to death in LIO in sheep. |
| 收录类别 | SCI |
| 原文出处 | 200428719.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5567]  |
| 专题 | 昆明动物研究所_生殖与发育生物学 |
| 作者单位 | Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li XL,Su L[*]. Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction[J]. VETERINARY RESEARCH COMMUNICATIONS,2004,28(8):719-725. |
| APA | Li XL,&Su L[*].(2004).Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction.VETERINARY RESEARCH COMMUNICATIONS,28(8),719-725. |
| MLA | Li XL,et al."Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction".VETERINARY RESEARCH COMMUNICATIONS 28.8(2004):719-725. |
入库方式： OAI收割
来源：昆明动物研究所
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