Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors
文献类型：期刊论文
| 作者 | Chen YC1,2; Niu YY[*]1,2; Ji WZ[*]1,3 |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2012 |
| 卷号 | 39期号:6页码:247-251 |
| 关键词 | Nonhuman primates Disease model Transgenesis |
| 通讯作者 | niuyy@mail.kiz.ac.cn ; wji@kbimed.com |
| 英文摘要 | Nonhuman primates (NHPs) provide powerful experimental models to study human development, cognitive functions and disturbances as well as complex behavior, because of their genetic and physiological similarities to humans. Therefore, NHPs are appropriate models for the study of human diseases, such as neurodegenerative diseases including Parkinson's, Alzheimer's and Huntington's diseases, which occur as a result of genetic mutations. However, such diseases afflicting humans do not occur naturally in NHPs. So transgenic NHPs need to be established to understand the etiology of disease pathology and pathogenesis. Compared to rodent genetic models, the generation of transgenic NHPs for human diseases is inefficient, and only a transgenic monkey model for Huntington's disease has been reported. This review focuses on potential approaches and contributing factors for generating transgenic NHPs to study human diseases. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the grants from the Major State Basic Development Program (No. 2012CBA01300), the National High Technology Research and Development Program (No. 2012AA020701), the National Science and Technology Major Project (No. 2009ZX09501- 028) and the Social Science and Technology Development Program of Yunnan Province (No. 2007GH). |
| 语种 | 英语 |
| WOS记录号 | WOS:000305958500003 |
| 公开日期 | 2012-09-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7008]  |
| 专题 | 昆明动物研究所_生殖与发育生物学 |
| 作者单位 | 1.Yunnan Key Laboratory of Primate Biomedical Research, Kunming 650500, China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Kunming Biomed International and National Engineering Research Center of Biomedicine and Animal Science, Kunming 650500, China |
| 推荐引用方式 GB/T 7714 | Chen YC,Niu YY[*],Ji WZ[*]. Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors[J]. JOURNAL OF GENETICS AND GENOMICS,2012,39(6):247-251. |
| APA | Chen YC,Niu YY[*],&Ji WZ[*].(2012).Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors.JOURNAL OF GENETICS AND GENOMICS,39(6),247-251. |
| MLA | Chen YC,et al."Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors".JOURNAL OF GENETICS AND GENOMICS 39.6(2012):247-251. |
入库方式： OAI收割
来源：昆明动物研究所
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