Neural lineage development in the rhesus monkey with embryonic stem cells
文献类型：期刊论文
| 作者 | Chen HW[*]1,2,3,5; Wei Q1,2,5; Zhang J1,2,5; Tan T1,2,5; Li RR1,2,5; Chen JL4 |
| 刊名 | TRANSLATIONAL NEUROSCIENCE
 |
| 出版日期 | 2013 |
| 卷号 | 4期号:3页码:378-384 |
| 关键词 | Differentiation Neurogenesis Gliogenesis Neuroepithelial stem/progenitor cell (NEP) Radial glia (RG) |
| 通讯作者 | chenhw02@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | There are three controversial and undetermined models of neurogenesis and gliogenesis from neuroepithelial cells in the early neural tube; the first in which neurons and glia were proposed to originate from a single homogenous population, the second from two separate pools of committed glial and neuronal progenitors, or, lastly, from transit radial glial (RG). Issues concerning embryonic neural lineage development in primates are not well understood due to restrictions imposed by ethics and material sources. In this study, early neural lineage development was investigated in vitro with rhesus monkey embryonic stem cells (rESC) by means of immunofluorescence with lineage specific markers. It was revealed that neural differentiation likely progresses in a sequential lineage restriction pathway from neuroepithelial stem/progenitor cells to neurons and glia via RG and intermediate precursors: neuronal precursors and glial progenitors. In conclusion, our results suggest that the early neural lineage development of rESC in vitro supported the model in which neuroepithelial cells develop into RG capable of generating both neurons and glia. This work should facilitate understanding of the mechanism of development of the nervous system in primates. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by research grants from the National Basic Research Program 2006CB701505 and 2007CB947701, the Chinese Academy of Sciences KSCX2-YW-R-47, and the Chinese National Science Foundation 30570906 and 30700159. |
| 语种 | 英语 |
| WOS记录号 | WOS:000324324900012 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7694]  |
| 专题 | 昆明动物研究所_生殖与发育生物学 |
| 作者单位 | 1.Laboratory of Reproductive and Developmental Biology, Kunming Primate Research Center, and Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P. R. China 2.Yunnan Key Laboratory of Animal Reproductive Biology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P. R. Chin 3.School of Life Sciences and Chemistry, Zhaotong University, Zhaotong, Yunnan 657000, P.R. China 4.Zhaotong University, Zhaotong, Yunnan 657000, P.R. China 5.Graduate University of Chinese Academy of Sciences, Beijing 100049, P. R. China |
| 推荐引用方式 GB/T 7714 | Chen HW[*],Wei Q,Zhang J,et al. Neural lineage development in the rhesus monkey with embryonic stem cells[J]. TRANSLATIONAL NEUROSCIENCE,2013,4(3):378-384. |
| APA | Chen HW[*],Wei Q,Zhang J,Tan T,Li RR,&Chen JL.(2013).Neural lineage development in the rhesus monkey with embryonic stem cells.TRANSLATIONAL NEUROSCIENCE,4(3),378-384. |
| MLA | Chen HW[*],et al."Neural lineage development in the rhesus monkey with embryonic stem cells".TRANSLATIONAL NEUROSCIENCE 4.3(2013):378-384. |
入库方式： OAI收割
来源：昆明动物研究所
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