Notch1 Signaling Antagonizes Transforming Growth Factor- b Pathway and Induces Apoptosis in Rabbit Trophoblast Stem Cells
文献类型：期刊论文
| 作者 | Tan T1,2,3; Lu B1,2,3,4; Zhang J1,2; Niu YY1,2; Si W1,2; Wei Q1,2; Ji WZ[*]1,2 |
| 刊名 | STEM CELLS AND DEVELOPMENT
 |
| 出版日期 | 2014 |
| 卷号 | 23期号:8页码:813-822 |
| 通讯作者 | wji@kbimed.com |
| 英文摘要 | During mammalian development, placental growth needs to be tightly controlled by apoptosis. However, despite the potentially significant problems, the strategies used to balance growth and apoptosis have remained elusive. Here we report that activation of the Notch1 signal pathway inhibits transduction of transforming growth factor (TGF)- signaling, which leads to cell cycle arrest and apoptosis in rabbit trophoblast stem cells (TSCs). The subcellular location of notch intracellular domain 1 (NICD1) appears to determine whether TGF- signaling will be inhibited or not. Moreover, changes in NICD1 subcellular location are regulated by intracellular calcium distribution. Collectively, these results establish a potential mechanism whereby TSCs can balance growth and apoptosis, and thus guarantee the development of the fetus. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Program on Key Basic Research Project of China (973 Program; grant no. 2012CBA01307), National High-tech R&D Program of China (863 Program; grant no. 2012AA020701), and Na- tional Natural Science Fund for Young Scholars Grant (grant no. 31101066). |
| 语种 | 英语 |
| WOS记录号 | WOS:000333814500003 |
| 公开日期 | 2014-10-16 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8054]  |
| 专题 | 昆明动物研究所_生殖与发育生物学 |
| 作者单位 | 1.Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China 2.Kunming Biomed International and National Engineering Research Center of Biomedicine and Animal Science, Kunming, Yunnan, China 3.Laboratory of Reproductive and Developmental Biology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 4.Graduate School of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Tan T,Lu B,Zhang J,et al. Notch1 Signaling Antagonizes Transforming Growth Factor- b Pathway and Induces Apoptosis in Rabbit Trophoblast Stem Cells[J]. STEM CELLS AND DEVELOPMENT,2014,23(8):813-822. |
| APA | Tan T.,Lu B.,Zhang J.,Niu YY.,Si W.,...&Ji WZ[*].(2014).Notch1 Signaling Antagonizes Transforming Growth Factor- b Pathway and Induces Apoptosis in Rabbit Trophoblast Stem Cells.STEM CELLS AND DEVELOPMENT,23(8),813-822. |
| MLA | Tan T,et al."Notch1 Signaling Antagonizes Transforming Growth Factor- b Pathway and Induces Apoptosis in Rabbit Trophoblast Stem Cells".STEM CELLS AND DEVELOPMENT 23.8(2014):813-822. |
入库方式： OAI收割
来源：昆明动物研究所
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