Host-Parasite Interactions and Purifying Selection in a Microsporidian Parasite of Honey Bees
文献类型：期刊论文
| 作者 | Huang Q[*]1,2; Chen YP2; Wang RW[*]1,3; Cheng S4; Evans JD[*]2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2016 |
| 卷号 | 11期号:2页码:e0147549 |
| 通讯作者 | qiang-huang@live.com ; Jay.Evans@ars.usda.gov |
| 英文摘要 | To clarify the mechanisms of Nosema ceranae parasitism, we deep-sequenced both honey bee host and parasite mRNAs throughout a complete 6-day infection cycle. By time-series analysis, 1122 parasite genes were significantly differently expressed during the reproduction cycle, clustering into 4 expression patterns. We found reactive mitochondrial oxygen species modulator 1 of the host to be significantly down regulated during the entire infection period. Our data support the hypothesis that apoptosis of honey bee cells was suppressed during infection. We further analyzed genome-wide genetic diversity of this parasite by comparing samples collected from the same site in 2007 and 2013. The number of SNP positions per gene and the proportion of non-synonymous substitutions per gene were significantly reduced over this time period, suggesting purifying selection on the parasite genome and supporting the hypothesis that a subset of N. ceranae strains might be dominating infection. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the United States Department of Agriculture—National Institute of Food and Agriculture- 2014-67013-21784. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10319]  |
| 专题 | 昆明动物研究所_实验与理论生态学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, 650223, China 2.USDA-ARS Bee Research Laboratory, BARC-East Building 306, Beltsville, Maryland, 20705, United States of America 3.Center for Ecological and Environmental Science, Northwestern Polytechnical University, Xi’an, 710072, China 4.Chongqing Academy of Animal Science, Chongqing, 402460, China |
| 推荐引用方式 GB/T 7714 | Huang Q[*],Chen YP,Wang RW[*],et al. Host-Parasite Interactions and Purifying Selection in a Microsporidian Parasite of Honey Bees[J]. PLOS ONE,2016,11(2):e0147549. |
| APA | Huang Q[*],Chen YP,Wang RW[*],Cheng S,&Evans JD[*].(2016).Host-Parasite Interactions and Purifying Selection in a Microsporidian Parasite of Honey Bees.PLOS ONE,11(2),e0147549. |
| MLA | Huang Q[*],et al."Host-Parasite Interactions and Purifying Selection in a Microsporidian Parasite of Honey Bees".PLOS ONE 11.2(2016):e0147549. |
入库方式： OAI收割
来源：昆明动物研究所
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