Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats
文献类型：期刊论文
| 作者 | Zhang LH1,2; Xu L3; Xu TL[*]1,2 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 344期号:3页码:721-726 |
| 关键词 | glycine receptor GABA(A) receptor hippocampus brain slice synaptic transmission short-term plasticity paired-pulse depression paired-pulse facilitation |
| ISSN号 | 0006-291X |
| 通讯作者 | tlxu@ion.ac.cn, xutianle@ustc.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their roles in synaptic transmission are unclear. In this study, we examined the effect of GlyR activation on paired-pulse stimulation of the whole-cell postsynaptic currents (PSCs) in the Schaffer-CA1 synapses in rat hippocampal slices. Bath application of glycine reduced the amplitude of PSCs, accompanied by all increase ill holding current and resting conductance. Moreover, glycine application increased the paired-pulse ratio (PPR) of PSCs significantly, all effect largely abolished by the GlyR specific antagonist strychnine. Interestingly, glycine application had no significant effect oil either the amplitude or the PPR of excitatory postsynaptic currents (EPSCs). Our findings suggest that GlyR activation regulates hippocampal short-term plasticity by altering GABAergic neurotransmission. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Basic Re- search Program of China (No. 2006CB500803) and the National Natural Science Foundation of China (Nos. 30125015 and 30321002) to T.-L. Xu. |
| 原文出处 | 2006344721.pdf |
| 语种 | 中文 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5893]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.School of Life Sciences, University of Science and Technology of China, Hefei 230027, China 2.Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai 200031, China 3.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Zhang LH,Xu L,Xu TL[*]. Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,344(3):721-726. |
| APA | Zhang LH,Xu L,&Xu TL[*].(2006).Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,344(3),721-726. |
| MLA | Zhang LH,et al."Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 344.3(2006):721-726. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。