Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study
文献类型：期刊论文
| 作者 | Li LJ[*]1; Ma N1; Li ZX1; Tan LW1; Liu J2; Gong GL3; Shu N3; He Z2; Jiang TZ[*]3; Xu L4 |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2007 |
| 卷号 | 1168期号:X页码:124-128 |
| 关键词 | major depressive disorder DTI white matter fractional anisotropy young adult |
| ISSN号 | 0006-8993 |
| 通讯作者 | llj2920@163.com ; jiangtz@nlpr.ia.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Prefrontal impairments have been hypothesized to be most strongly associated with the cognitive and emotional dysfunction in depression. Recently, white matter microstructural abnormalities in prefrontal lobe have been reported in elderly patients with major depressive disorder (MDD) using diffusion tensor imaging (DTI). However, it is still unclear whether the same changes exist in younger patients. In the present study, we first utilized DTI to detect prefrontal white matter in young adults with MDD. Nineteen first-episode, untreated young adults with MDD and twenty age- and gender-matched healthy controls were recruited. DTI and localizing anatomic data were acquired. Then, the regions of interest (ROIs) were located in prefrontal white matter at 4 mm inferior, and 0, 4, 8,12,16 and 20 mm superior to the anterior commissure-posterior commissure (AC-PC) plane, respectively. Compared with healthy controls, patients with MDD showed significantly lower fractional anisotropy (FA) values in prefrontal white matter at bilateral 20 mm, right 16 mm and right 12 mm above the AC-PC. Furthermore, there was no significant correlation between the FA value of any ROI and illness course as well as severity of depression. Together with previous findings, the present results suggest that microstructural abnormalities in prefrontal white matter may occur early in the course of MDD and may be related to the neuropathology of depression throughout adulthood from young to elderly. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by research grants from National Natural Science Foundation (30670751 and 30470621 to L.J.L., 30570509 and 30425004 to T.Z.J.) National Science and Tech- nology Program (2007BAI17B02 to L.J.L. and N.M.) and National 973 Program (2006CB500800 to L.J.L. and L.X.) of China. |
| 原文出处 | 20071168124.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5903]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Mental Health Institute, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China 2.Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China 3.National Laboratory of Pattern Recognition, Automation Institute, Chinese Academy of Sciences, Beijing, China 4.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Li LJ[*],Ma N,Li ZX,et al. Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study[J]. BRAIN RESEARCH,2007,1168(X):124-128. |
| APA | Li LJ[*].,Ma N.,Li ZX.,Tan LW.,Liu J.,...&Xu L.(2007).Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study.BRAIN RESEARCH,1168(X),124-128. |
| MLA | Li LJ[*],et al."Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study".BRAIN RESEARCH 1168.X(2007):124-128. |
入库方式： OAI收割
来源：昆明动物研究所
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