Distinct neurobehavioral consequences of prenatal exposure to sulpiride (SUL) and risperidone (RIS) in rats
文献类型：期刊论文
| 作者 | Zuo J1; Liu ZN[*]1; Ouyang X1; Liu HH1; Hao YH1; Xu L1,2; Lu XH[*]1,3 |
| 刊名 | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
 |
| 出版日期 | 2008 |
| 卷号 | 32期号:2页码:387-397 |
| 关键词 | body growth fetal exposure locomotion risperidone sulpiride water maze |
| ISSN号 | 0278-5846 |
| 通讯作者 | zningl@163.corn ; xlu@mednet.ucla.edu |
| 合作状况 | 其它 |
| 英文摘要 | Antipsychotic treatment during pregnancy is indicated when risk of drug exposure to the fetus is outweighed by the untreated psychosis in the mother. Although increased risk of congenital malformation has not been associated with most available antipsychotic drugs, there is a paucity of knowledge on the subtle neurodevelopmental and behavioral consequences of prenatal receptor blockade by these drugs. In the present study, antipsychotic drugs, sulpiride (SUL, a selective D2 receptor antagonist) and risperidone (RIS, a D2/5HT2 receptor antagonist) were administered to pregnant Sprague-Dawley dams from gestational day 6 to 18. Both RIS and SUL prenatal exposed rats had lower birth body weights compared to controls. RIS exposure had a significant main effect to retard body weight growth in male offspring until postnatal day (PND) 60. Importantly, water maze tests revealed that SUL prenatal exposure impaired visual cue response in visual task performance (stimulus-response, S-R memory), but not place response as reflected in hidden platform task (spatial memory acquisition and retention). In addition, prenatal SUL treatment reduced spontaneous activity as measured in open field. Both behavioral deficits suggest that SUL prenatal exposure may lead to subtle disruption of striatum development and related learning and motor systems. RIS exposure failed to elicit deficits in both water maze tasks and increased rearing in open field test. These results suggest prenatal exposure to SUL and RIS may produce lasting effects on growth, locomotion and memory in rat offspring. And the differences may exist in the effects of antipsychotic drugs which selectively block dopamine D2 receptors (SUL) as compared to second generation drugs (RIS) that potently antagonize serotonin and dopamine receptors. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Grants (30670752), the University Creativity Grants of Central South University, China, and the National Key Basic Research and Development Program (973), Grant No. 2006CB500808. |
| 原文出处 | 200832387.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5921]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Institute of Mental Health, the second Xiang-Ya hospital, Central South University, Changsha, Hunan, 410011, PR China 2.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China 3.Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA |
| 推荐引用方式 GB/T 7714 | Zuo J,Liu ZN[*],Ouyang X,et al. Distinct neurobehavioral consequences of prenatal exposure to sulpiride (SUL) and risperidone (RIS) in rats[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2008,32(2):387-397. |
| APA | Zuo J.,Liu ZN[*].,Ouyang X.,Liu HH.,Hao YH.,...&Lu XH[*].(2008).Distinct neurobehavioral consequences of prenatal exposure to sulpiride (SUL) and risperidone (RIS) in rats.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,32(2),387-397. |
| MLA | Zuo J,et al."Distinct neurobehavioral consequences of prenatal exposure to sulpiride (SUL) and risperidone (RIS) in rats".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 32.2(2008):387-397. |
入库方式： OAI收割
来源：昆明动物研究所
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