Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition
文献类型：期刊论文
| 作者 | Zhang LH1,2; Gong N1,2; Fei D1; Xu L3; Xu TL[*]1 |
| 刊名 | NEUROPSYCHOPHARMACOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 33期号:3页码:701-711 |
| 关键词 | glycine receptor glycine transporter hippocampus EPSP-spike coupling tonic inhibition glia |
| ISSN号 | 0893-133X |
| 通讯作者 | tlxu@ion.ac.cn |
| 合作状况 | 其它 |
| 中文摘要 | Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their role in hippocampal function remains unclear. Since the concentration of ambient glycine is determined by the presence of powerful glycine transporter (GlyT), we blocked the reuptake of glycine in hippocampal slices to examine the role of GlyRs. Antagonists of GlyT type 1 (GlyT1) but not that of GlyT type 2 (GlyT2) induced excitatory postsynaptic potential (EPSP)-spike depression, which was reversed by the specific GlyR antagonist strychnine. Moreover, endogenously elevating the glycine concentration with the GlyT1 antagonists facilitated NMDA receptor-dependent longterm potentiation induction, and elicited a strychnine-sensitive chloride current. In addition, impairment of glial function with fluoroacetate blocked the effect of GlyT1 antagonists on the EPSP-spike curve. Furthermore, pretreatment with sarcosine was effective in controlling pentylenetetrazol-induced seizures. These results indicate an essential role of GlyTs in fine-tuning tonic activation of GlyRs and suggest a potential role of GlyR-dependent EPSP-spike depression in hippocampal network stability. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). |
| 原文出处 | 200833701.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5923]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China 2.School of Life Sciences, University of Science and Technology of China, Hefei, China 3.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Zhang LH,Gong N,Fei D,et al. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition[J]. NEUROPSYCHOPHARMACOLOGY,2008,33(3):701-711. |
| APA | Zhang LH,Gong N,Fei D,Xu L,&Xu TL[*].(2008).Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition.NEUROPSYCHOPHARMACOLOGY,33(3),701-711. |
| MLA | Zhang LH,et al."Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition".NEUROPSYCHOPHARMACOLOGY 33.3(2008):701-711. |
入库方式： OAI收割
来源：昆明动物研究所
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