GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation
文献类型：期刊论文
| 作者 | Gong N1,2; Li Y3; Cai GQ4; Niu RF5; Fang Q1,2,6; Wu K1,2,7; Chen Z6; Lin LN5; Xu L1,2,7; Fei J4 |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2009 |
| 卷号 | 29期号:50页码:15836-15845 |
| ISSN号 | 0270-6474 |
| 通讯作者 | tlxu@ion.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The network oscillation and synaptic plasticity are known to be regulated by GABAergic inhibition, but how they are affected by changes in the GABA transporter activity remains unclear. Here we show that in the CA1 region of mouse hippocampus, pharmacological blockade or genetic deletion of GABA transporter-1 (GAT1) specifically impaired long-term potentiation (LTP) induced by theta burst stimulation, but had no effect on LTP induced by high-frequency stimulation or long-term depression induced by low-frequency stimulation. The extent of LTP impairment depended on the precise burst frequency, with significant impairment at 3-7 Hz that correlated with the time course of elevated GABAergic inhibition caused by GAT1 disruption. Furthermore, in vivo electrophysiological recordings showed that GAT1 gene deletion reduced the frequency of hippocampal theta oscillation. Moreover, behavioral studies showed that GAT1 knock-out mice also exhibited impaired hippocampus-dependent learning and memory. Together, these results have highlighted the important link between GABAergic inhibition and hippocampal theta oscillation, both of which are critical for synaptic plasticity and learning behaviors. |
| 收录类别 | SCI |
| 资助信息 | ThisstudywassupportedbygrantstoT.-L.XufromtheNationalNaturalScienceFoundationofChina(30621062 and30830035),theNationalBasicResearchProgramofChina(2006CB500803),theKnowledgeInnovationProjects fromtheChineseAcademyofSciences(KSCX2-YW-R-35andKSCX2-YW-R-100).N.G.wasarecipientoffundsfrom theChinaPostdoctoralScienceFoundation,theShanghaiPostdoctoralScientificProgram,andthePostdoctorRe- searchProgramofShanghaiInstitutesforBiologicalSciences,ChineseAcademyofSciences. |
| 原文出处 | 2009295015836.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5925]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 3.Shanghai Jiao Tong Univ, Inst Med Sci, Dept Neurobiol, Shanghai 200025, Peoples R China 4.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China 5.E China Normal Univ, Shanghai Inst Brain Funct Genom, Shanghai 200062, Peoples R China 6.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China 7.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong N,Li Y,Cai GQ,et al. GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation[J]. JOURNAL OF NEUROSCIENCE,2009,29(50):15836-15845. |
| APA | Gong N.,Li Y.,Cai GQ.,Niu RF.,Fang Q.,...&Xu TL[*].(2009).GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation.JOURNAL OF NEUROSCIENCE,29(50),15836-15845. |
| MLA | Gong N,et al."GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation".JOURNAL OF NEUROSCIENCE 29.50(2009):15836-15845. |
入库方式： OAI收割
来源：昆明动物研究所
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