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Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex

文献类型：期刊论文

作者Hao YH1; Yan Q2; Liu HH1; Xu L1,3; Xue ZM1; Song XQ4; Kaneko Y5; Jiang TZ6; Liu ZN[*]1; Shan BC[*]2
刊名SCHIZOPHRENIA RESEARCH
出版日期2009
卷号114期号:37624页码:18-135
关键词Schizophrenia Healthy siblings Diffusion tensor imaging Fractional anisotropy
ISSN号0920-9964
通讯作者zningl@163.com ; shanbc@mail.ihep.ac.cn
合作状况其它
英文摘要Healthy siblings of schizophrenia patients have an almost 9-fold higher risk for developing the illness than the general population. Disruption of white matter (WM) integrity as indicated by reduced fractional anisotropy (FA) derived from diffusion tensor imaging (DTI), is believed to be the key substrate of schizophrenia. However, it remains unclear whether schizophrenia patients and their healthy siblings share a specific pattern of disruption of WM integrity that may be related to the disease risk. The objective of this study is to determine whether a specific brain regional pattern of disruption of WM integrity is shared by schizophrenia patients and their healthy siblings. We investigated brain white matter abnormalities by voxel-based analysis of white matter FA data acquired from diffusion tensor imaging in 34 pairs of schizophrenia patients and their healthy siblings, as well as in 32 healthy controls. Both schizophrenia patients and their healthy siblings showed reduced white matter FA in the left prefrontal cortex and the hippocampus in comparison to healthy controls, without significant difference between patients and siblings. In marked contrast, only schizophrenia patients exhibited reduced white matter FA in the left anterior cingulate cortex in comparison to both siblings and controls, without significant difference between siblings and controls. Thus, schizophrenia patients and their healthy siblings share disruption of WM integrity in the left prefrontal cortex and the hippocampus that may be related to higher risk of healthy siblings to develop schizophrenia, which may be eventually attributed to additional disruption of WM integrity in the left anterior cingulate cortex.
收录类别SCI
资助信息Funding for this study was provided by grants from the National Natural Science Foundation of China (30670752 to Zhening Liu) and Basic Research Program (973) from the Ministry of Science and Technology of China (2006CB500808 and 2007CB512300 to Zhening L
原文出处2009114128.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/5927]  
专题昆明动物研究所_学习记忆的分子神经机制
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, PR China
2.Key Laboratory of Nuclear Analysis, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, PR China
3.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, PR China
4.Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, PR Chin
5.Yale University School of Medicine, New Haven, CT, USA
6.National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, PR China
推荐引用方式
GB/T 7714		 Hao YH,Yan Q,Liu HH,et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex[J]. SCHIZOPHRENIA RESEARCH,2009,114(37624):18-135.
APA Hao YH.,Yan Q.,Liu HH.,Xu L.,Xue ZM.,...&Shan BC[*].(2009).Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex.SCHIZOPHRENIA RESEARCH,114(37624),18-135.
MLA Hao YH,et al."Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex".SCHIZOPHRENIA RESEARCH 114.37624(2009):18-135.

入库方式： OAI收割

来源：昆明动物研究所

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