Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry
文献类型：期刊论文
| 作者 | Liu HH1; Hao YH1; Kaneko Y2; Ouyang X1; Zhang Y1; Xu L1,3; Xue ZM[*]1; Liu ZN[*]1 |
| 刊名 | PSYCHIATRY AND CLINICAL NEUROSCIENCES
 |
| 出版日期 | 2009 |
| 卷号 | 63期号:4页码:563-568 |
| ISSN号 | 1323-1316 |
| 关键词 | brain imaging gray matter heroin voxel-based morphometry |
| 通讯作者 | x.zhimin@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Aims: Repeated exposure to heroin, a typical opiate, causes neuronal adaptation and may result in anatomical changes in specific brain regions, particularly the frontal and limbic cortices. The volume changes of gray matter (GM) of these brain regions, however, have not been identified in heroin addiction. Methods: Using structural magnetic resonance imaging and an optimized voxel-based morphometry approach, the GM volume difference between 15 Chinese heroin-dependent and 15 healthy subjects was tested. Results: Compared to healthy subjects, the heroin-dependent subjects had reduced GM volume in the right prefrontal cortex, left supplementary motor cortex and bilateral cingulate cortices. Conclusion: Frontal and cingulate atrophy may be involved in the neuropathology of heroin dependence. |
| 资助信息 | The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu). |
| 收录类别 | SCI |
| 原文出处 | 2009634563.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5931]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan 2.Yale University School of Medicine, New Haven, Connecticut, USA 3.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology of Chinese Academy of Science, Kuming, Yunnan, Chin |
| 推荐引用方式 GB/T 7714 | Liu HH,Hao YH,Kaneko Y,et al. Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry[J]. PSYCHIATRY AND CLINICAL NEUROSCIENCES,2009,63(4):563-568. |
| APA | Liu HH.,Hao YH.,Kaneko Y.,Ouyang X.,Zhang Y.,...&Liu ZN[*].(2009).Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry.PSYCHIATRY AND CLINICAL NEUROSCIENCES,63(4),563-568. |
| MLA | Liu HH,et al."Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry".PSYCHIATRY AND CLINICAL NEUROSCIENCES 63.4(2009):563-568. |
入库方式： OAI收割
来源：昆明动物研究所
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