中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 昆明动物研究所
  3. 昆明动物研究所
  4. 动物模型与人类重大疾病机理重点实验室
  5. 学习记忆的分子神经机制
Sensory input is required for callosal axon targeting in the somatosensory cortex

文献类型：期刊论文

作者Huang Y1,2; Song NN1,2; Lan W1,2; Zhang Q1,2; Zhang L1,2; Zhang L1,2; Hu L1,2; Chen JY1,2; Zhao CJ3; Li LJ4
刊名MOLECULAR BRAIN
出版日期2013
卷号6期号:X页码:e53
关键词Callosal projection Sensory input Axon pathfinding Somatosensory cortex
通讯作者dingyuqiang@gmail.com
合作状况其它
英文摘要Background: Sensory input is generally thought to be necessary for refining and consolidating neuronal connections during brain development. We here report that cortical callosal axons in somatosensory cortex require sensory input for their target selection in contralateral cortex.

Results: Eliminating sensory input to either hemisphere by unilateral transection of infraorbital nerve (ION) prevents target selection of callosal axons in contralateral cortex. Strikingly, blocking sensory input bilaterally, by simultaneously transecting both IONs, results in rescued callosal projection. In contrast, non-simultaneous bilateral ION transection has the same effect as unilateral transection. Similar results are obtained by lesion of whisker hair follicles. c-Fos-positive neurons in brain slices treated with KCl is decreased more in contralateral cortex with unilateral removal of sensory input, but decreased similarly in both cortices in mice with simultaneous bilateral removal of sensory input. Frequency of sEPSC of cortical neurons is also reduced in contralateral cortex with the unilateral removal of sensory input, but equally reduced on both sides with the bilateral removal of sensory input, suggesting that unbalanced bilateral sensory input might lead to mismatched neuronal activity between the two cortices and contribute to the formation of callosal projection.

Conclusion: Our data demonstrate a critical role of balanced bilateral somatosensory input in the formation of callosal connections, and thus reveal a new role of sensory input in wiring brain circuits.
收录类别SCI
资助信息This work was supported by the National Natural Science Foundation of China (81221001, 91232724, 81101026, 31100788, 31030034), Key State Research Program from Ministry of Science and Technology of China (2012CB966900, 2011CB510005), Science and Technology Commission of Shanghai Municipality (11140902200, 12XD1404800) and Fundamental Research Funds for the Central Universities.
语种英语
WOS记录号WOS:000328843800001
公开日期2014-01-17
源URL[http://159.226.149.42:8088/handle/152453/7776]  
专题昆明动物研究所_学习记忆的分子神经机制
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.Key Laboratory of Arrhythmias, Ministry of Education, East Hospitial, Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China
2.Department of Anatomy and Neurobiology, Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China
3.Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, School of Huang et al. Molecular Brain 2013, 6:53 Page 11 of 12 http://www.molecularbrain.com/content/6/1/53 Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China
4.Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha 410011, China
5.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China.
推荐引用方式
GB/T 7714		 Huang Y,Song NN,Lan W,et al. Sensory input is required for callosal axon targeting in the somatosensory cortex[J]. MOLECULAR BRAIN,2013,6(X):e53.
APA Huang Y.,Song NN.,Lan W.,Zhang Q.,Zhang L.,...&Ding YQ[*].(2013).Sensory input is required for callosal axon targeting in the somatosensory cortex.MOLECULAR BRAIN,6(X),e53.
MLA Huang Y,et al."Sensory input is required for callosal axon targeting in the somatosensory cortex".MOLECULAR BRAIN 6.X(2013):e53.

入库方式： OAI收割

来源：昆明动物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。