Fluoxetine Pretreatment Promotes Neuronal Survival and Maturation after Auditory Fear Conditioning in the Rat Amygdala
文献类型：期刊论文
| 作者 | Jiang LZ1,5; Liu C2; Tong JB3; Mao RR4; Chen D2; Wang H2; Huang JF[*]2; Li LJ[*]1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:2页码:e89147 |
| 通讯作者 | huangjufang@csu.edu.cn ; llj2920@163.com |
| 合作状况 | 其它 |
| 英文摘要 | The amygdala is a critical brain region for auditory fear conditioning, which is a stressful condition for experimental rats. Adult neurogenesis in the dentate gyrus (DG) of the hippocampus, known to be sensitive to behavioral stress and treatment of the antidepressant fluoxetine (FLX), is involved in the formation of hippocampus-dependent memories. Here, we investigated whether neurogenesis also occurs in the amygdala and contributes to auditory fear memory. In rats showing persistent auditory fear memory following fear conditioning, we found that the survival of new-born cells and the number of new-born cells that differentiated into mature neurons labeled by BrdU and NeuN decreased in the amygdala, but the number of cells that developed into astrocytes labeled by BrdU and GFAP increased. Chronic pretreatment with FLX partially rescued the reduction in neurogenesis in the amygdala and slightly suppressed the maintenance of the long-lasting auditory fear memory 30 days after the fear conditioning. The present results suggest that adult neurogenesis in the amygdala is sensitive to antidepressant treatment and may weaken long-lasting auditory fear memory. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (3086008 to Lizhu Jiang; 31100786 to Rongrong Mao; 930830046, 81171286, and 91232714 to Lingjiang Li), the National 973 Program of China (2009CB918303 to Lingjiang Li), and the Program of the Chinese Ministry of Education (20090162110011 to Lingjiang Li). |
| 语种 | 英语 |
| WOS记录号 | WOS:000331266000108 |
| 公开日期 | 2014-03-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7825]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Mental Health Institute, The Second Xiangya Hospital, and Key Lab of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, China 2.Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China 3.The Third Xiangya Hospital, Central South University, Changsha, China 4.Key Lab of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China 5.Department of neuropsychopathy, clinical medical school, Dali University, Dali, China |
| 推荐引用方式 GB/T 7714 | Jiang LZ,Liu C,Tong JB,et al. Fluoxetine Pretreatment Promotes Neuronal Survival and Maturation after Auditory Fear Conditioning in the Rat Amygdala[J]. PLOS ONE,2014,9(2):e89147. |
| APA | Jiang LZ.,Liu C.,Tong JB.,Mao RR.,Chen D.,...&Li LJ[*].(2014).Fluoxetine Pretreatment Promotes Neuronal Survival and Maturation after Auditory Fear Conditioning in the Rat Amygdala.PLOS ONE,9(2),e89147. |
| MLA | Jiang LZ,et al."Fluoxetine Pretreatment Promotes Neuronal Survival and Maturation after Auditory Fear Conditioning in the Rat Amygdala".PLOS ONE 9.2(2014):e89147. |
入库方式： OAI收割
来源：昆明动物研究所
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