Maternal separation exaggerates spontaneous recovery of extinguished contextual fear in adult female rats
文献类型：期刊论文
| 作者 | Xiong GJ1,2; Yang Y3; Wang LP1; Xu L[*]1; Mao RR[*]1 |
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 269期号:X页码:75-80 |
| 关键词 | Contextual fear extinction Female Long-term potentiation Maternal separation Spontaneous recovery |
| 通讯作者 | lxu@vip.163.com ; talktomaomao@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Early life stress increases the risk of posttraumatic stress disorders (PTSD). Patients with PTSD show impaired extinction of traumatic memory, and in women, this occurs more often when PTSD is preceded by child trauma. However, it is still unclear how early life stress accounts for extinction impairment. Here, we studied the effects of maternal separation (MS, postnatal day 2 to 14) on contextual fear extinction in adult female rats. Additionally, to examine changes in synaptic function affected by MS, we measured long-term potentiation (LTP) in prefrontal cortex and hippocampus in vitro, both of which have been implicated in fear extinction. We found that adult female rats had been subjected to MS exhibited significant spontaneous recovery of fear to the extinguished context. Furthermore, MS exposure resulted in LTP impairment in both infralimbic prefrontal cortex layer 2/3-layer 5 and hippocampal SC-CA1 pathways. Interestingly, no obvious effects of MS on contextual fear conditioning, fear recall as well as extinction training and recall were observed. Innate fear in the elevated plus maze or open field test remained nearly unaffected. These findings provided the first evidence that MS may exaggerate spontaneous recovery after contextual fear extinction, for which LTP impairment in the medial prefrontal cortex and hippocampus may be responsible, thereby possibly leading to impaired extinction associated with PTSD. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). |
| 语种 | 英语 |
| WOS记录号 | WOS:000337866400011 |
| 公开日期 | 2014-06-06 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7895]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan 650223, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.Department of Physiology, Kunming Medical University, Kunming, Yunnan 650500, China |
| 推荐引用方式 GB/T 7714 | Xiong GJ,Yang Y,Wang LP,et al. Maternal separation exaggerates spontaneous recovery of extinguished contextual fear in adult female rats[J]. BEHAVIOURAL BRAIN RESEARCH,2014,269(X):75-80. |
| APA | Xiong GJ,Yang Y,Wang LP,Xu L[*],&Mao RR[*].(2014).Maternal separation exaggerates spontaneous recovery of extinguished contextual fear in adult female rats.BEHAVIOURAL BRAIN RESEARCH,269(X),75-80. |
| MLA | Xiong GJ,et al."Maternal separation exaggerates spontaneous recovery of extinguished contextual fear in adult female rats".BEHAVIOURAL BRAIN RESEARCH 269.X(2014):75-80. |
入库方式： OAI收割
来源：昆明动物研究所
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