Long-term effects of controllability or the lack of it on coping abilities and stress resilience in the rat
文献类型：期刊论文
| 作者 | Lucas M1; Ilin Y1,2; Anunu R1,2; Kehat O1; Xu L3,4,5; Desmedt A6; Richter-Levin G[*]1,2,7 |
| 刊名 | STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
 |
| 出版日期 | 2014 |
| 卷号 | 17期号:5页码:423-430 |
| 关键词 | mood disorders rat resilience Controllability coping behavior learned helplessness |
| 通讯作者 | galrichterlevin@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Findings suggest that stress-induced impaired learning and coping abilities may be attributed more to the psychological nature of the stressor, rather than its physical properties. It has been proposed that establishing controllability over stressors can ameliorate some of its effects on cognition and behavior. Gaining controllability was suggested to be associated with the development of stress resilience. Based on repeated exposure to the two-way shuttle avoidance task, we previously developed and validated a behavioral task that leads to a strict dissociation between gaining controllability (to the level that the associated fear is significantly reduced) and a fearful state of uncontrollability. Employing this protocol, we investigated here the impact of gaining or failing to gain emotional controllability on indices of anxiety and depression and on subsequent abilities to cope with positively or negatively reinforcing learning experiences. In agreement with previous studies, rats exposed to the uncontrollable protocol demonstrated high concentration of sera corticosterone, increased immobility, reduced duration of struggling in the forced swim test and impaired ability to acquire subsequent learning tasks. Achieving emotional controllability resulted in resilience to stress as was indicated by longer duration of struggling in the forced swim test, and enhanced learning abilities. Our prolonged training protocol, with the demonstrated ability of rats to gain emotional controllability, is proposed as a useful tool to study the neurobiological mechanisms of stress resilience. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by a 2007research grant to G.R-L from the Institute for the study of affective Neuroscience (ISAN) at the University of Haifa endowed by the Hope for Depression Research Foundation (HDRF), by a 1403/07 grant of the Israel Science Foundation, and by a grant from the German Israeli Project Cooperation (DIP). |
| 语种 | 英语 |
| WOS记录号 | WOS:000341306000006 |
| 公开日期 | 2014-10-16 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8068]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.The Institute for the Study of Affective Neuroscience (ISAN), University of Haifa, Haifa, Israel 2.‘‘Sagol’’ Department of Neurobiology, University of Haifa, Haifa, Israel 3.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, China 4.KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, China 5.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, China 6.Neurocentre Magendie, INSERM U862, Universite ´ de Bordeaux, Bordeaux, France 7.Department of Psychology, University of Haifa, Haifa, Israel |
| 推荐引用方式 GB/T 7714 | Lucas M,Ilin Y,Anunu R,et al. Long-term effects of controllability or the lack of it on coping abilities and stress resilience in the rat[J]. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS,2014,17(5):423-430. |
| APA | Lucas M.,Ilin Y.,Anunu R.,Kehat O.,Xu L.,...&Richter-Levin G[*].(2014).Long-term effects of controllability or the lack of it on coping abilities and stress resilience in the rat.STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS,17(5),423-430. |
| MLA | Lucas M,et al."Long-term effects of controllability or the lack of it on coping abilities and stress resilience in the rat".STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 17.5(2014):423-430. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。