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Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells

文献类型：期刊论文

作者Jia YF1,2; Song NN3,4; Mao RR1,2; Li JN1,2; Zhang Q3,4; Huang Y3,4; Zhang L3,4; Xu L[*]1,2; Han HL1,2; Ding YQ[*]3,4
刊名FRONTIERS IN BEHAVIORAL NEUROSCIENCE
出版日期2014
卷号8期号:X页码:e325
关键词diabetes mellitus anxiety depression serotonin Pet1 adult neurogenesis
通讯作者dingyuqiang@vip.163.com ; lxu@vip.163.com
合作状况其它
英文摘要Dysfunction of central serotonin (5-HT) system has been proposed to be one of the underlying mechanisms for anxiety and depression, and the association of diabetes mellitus and psychiatric disorders has been noticed by the high prevalence of anxiety/depression in patients with diabetes mellitus. This promoted us to examine these behaviors in central 5-HT-deficient mice and those also suffering with diabetes mellitus. Mice lacking either 5-HT or central serotonergic neurons were generated by conditional deletion of Tph2 or Lmx1b respectively. Simultaneous depletion of both central serotonergic neurons and pancreatic islet cells was achieved by administration of diphtheria toxin (DT) in Pet1-Cre;Rosa26-DT receptor (DTR) mice. The central 5-HT-deficient mice showed reduced anxiety-like behaviors as they spent more time in and entered more often into the light box in the light/dark box test compared with controls; similar results were observed in the elevated plus maze test. However, they displayed no differences in the immobility time of the forced swimming and tail suspension tests suggesting normal depression-like behaviors in central 5-HT-deficient mice. As expected, DT-treated Pet1-Cre;Rosa26-DTR mice lacking both central serotonergic neurons and pancreatic islet endocrine cells exhibited several classic diabetic symptoms. Interestingly, they displayed increased anxiety-like behaviors but reduced immobility time in the forced swimming and tail suspension tests. Furthermore, the hippocampal neurogenesis was dramatically enhanced in these mice. These results suggest that the deficiency of central 5-HT may not be sufficient to induce anxiety/depression-like behaviors in mice, and the enhanced hippocampal neurogenesis may contribute to the altered depression-like behaviors in the 5-HT-deficient mice with diabetes. Our current investigation provides understanding the relationship between diabetes mellitus and psychiatric disorders.
收录类别SCI
资助信息This work was supported by grants from National Basic Research Program of China (2013CB835100 and 2009CB941300), Strate- gic Priority Research Program of the Chinese Academy of Sci- ence (XDB02020200), the National Natural Science Foundation of China (81221001, 31030034, 91232724, 81200933, 81101026, 31100788, 31100786, U1032605 and U1132602), Fundamen- tal Research Funds for the Central Universities (2013KJ049), and Science and Technology Program of Yunnan Province (2013GA003).
语种英语
WOS记录号WOS:000342032100001
公开日期2014-10-20
源URL[http://159.226.149.42:8088/handle/152453/8108]  
专题昆明动物研究所_学习记忆的分子神经机制
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
2.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China
3.Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, China
4.Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai, China
推荐引用方式
GB/T 7714		 Jia YF,Song NN,Mao RR,et al. Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2014,8(X):e325.
APA Jia YF.,Song NN.,Mao RR.,Li JN.,Zhang Q.,...&Ding YQ[*].(2014).Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,8(X),e325.
MLA Jia YF,et al."Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8.X(2014):e325.

入库方式： OAI收割

来源：昆明动物研究所

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