Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors
文献类型：期刊论文
| 作者 | Xiong GJ1,2; Yang Y3; Cao J1; Mao RR[*]1; Xu L[*]1 |
| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 92期号:X页码:1-7 |
| 关键词 | Fluoxetine Maternal separation Fear extinction Offspring Intergenerational Anxiety |
| 通讯作者 | talktomaomao@163.com ; lxu@vip.163.com |
| 合作状况 | 其它 |
| 英文摘要 | Early life stress increase's risks of fear and anxiety related disorders in adulthood, which may be alleviated by fluoxetine treatment. However, the intergenerational impacts of maternal separation (MS) on fear and anxiety behaviors from father to their offspring are little known. And the potential effects of fluoxetine treatment on the intergenerational transmission have not been well tested. Here, we investigated whether fluoxetine can reverse the intergenerational effects of MS on fear and anxiety behaviors. The first generation (F1) male rats were exposed to MS 3 h daily from postnatal day 2-14 and then treated with fluoxetine for four weeks during adulthood before fear conditioning. We found that maternal separation significantly impaired contextual fear extinction in F1 adult male rats but not in their second generation (F2). Although no obvious effects of MS on anxiety were observed in F1 male rats, the F2 offspring displayed a phenotype of low anxiety-like behaviors despite they were reared in normal condition. Fluoxetine treatment in F1 males not only reversed the impairment of fear extinction in F1 males but also the low anxiety-like behaviors in their F2 offspring. These findings highlight the intergenerational impacts of early life stress on fear and anxiety behaviors, and provide a new sight of the intergenerational effect of fluoxetine therapy for early life stress related mental problems. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Basic Research Program of China (2013CB835103), and Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (31100786, 81171294, U1032605 and U1132602), Science and Technology Program of Yunnan Province (2013GA003 and 2013FA048). |
| 语种 | 英语 |
| WOS记录号 | WOS:000351793700001 |
| 公开日期 | 2015-04-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8309]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.Department of Physiology, Kunming Medical University, Kunming 650500, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Xiong GJ,Yang Y,Cao J,et al. Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors[J]. NEUROPHARMACOLOGY,2015,92(X):1-7. |
| APA | Xiong GJ,Yang Y,Cao J,Mao RR[*],&Xu L[*].(2015).Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors.NEUROPHARMACOLOGY,92(X),1-7. |
| MLA | Xiong GJ,et al."Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors".NEUROPHARMACOLOGY 92.X(2015):1-7. |
入库方式： OAI收割
来源：昆明动物研究所
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