Opioid addiction and withdrawal differentially drive long-term depression of inhibitory synaptic transmission in the hippocampus
文献类型：期刊论文
| 作者 | Han HL1,2,3; Dong ZF2; Jia YF3,4; Mao RR3; Zhou QX3; Yang YX3; Wang LP3; Xu L3; Cao J[*]3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:X页码:e9666 |
| 通讯作者 | juncao@vip.163.com |
| 合作状况 | 其它 |
| 英文摘要 | Addictive behavior is increasingly accepted as a drug-associated pathological memory in which the hippocampus is profoundly engaged. It has been well documented that adaptations of synaptic plasticity of excitatory transmission in the hippocampus may contribute to opioid addiction. However, it remains unknown whether and how adaptive changes of synaptic plasticity of inhibitory transmission in the hippocampus occurs during opioid abuse. Here, we reported that a single in vivo morphine exposure (SM) did not affect inhibitory long-term depression (I-LTD) in the hippocampus, compared with saline control; while repeated morphine exposure (RM) abolished this I-LTD. Interestingly, opioid withdrawal for 3-5 days after repeated (RMW), but not a single morphine exposure (SMW), largely enhanced I-LTD. More importantly, the I-LTD in single morphine treatment is dependent on presynaptic mechanism since it can be blocked by AM251, a selective cannabinoid receptor 1 antagonist. While the large I-LTD in RMW group is dependent on combinatorial presynaptic and postsynaptic mechanisms since it can be blocked by co-application of AM251 and L-type calcium channel blocker LaCl3. Thus, these results demonstrate that opioid use and withdrawal drive the dynamics of presynaptic and postsynaptic I- LTD expression in the hippocampus that may contribute to the persistent behavioral changes during opioid abuse. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from National Basic Research Program of China (2013CB835103, 2015CB553500 and 2014CB548100),StrategicPriority Research Program of the Chinese Academy of Science (XDB02020002), the National Natural Science Foundation of China (81471356, 81271221, U1032605, U1402226 and U1132602), Science and Technology Program of Yunnan Province (2013GA003 and 2013FA048). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9189]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China 2.Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint Laboratory of Bioresources and MolecularResearchinCommonDisease,andLaboratoryofLearningandMemory,KunmingInstituteofZoology,ChineseAcademy of Sciences, Kunming 650223, China 4.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Han HL,Dong ZF,Jia YF,et al. Opioid addiction and withdrawal differentially drive long-term depression of inhibitory synaptic transmission in the hippocampus[J]. SCIENTIFIC REPORTS,2015,5(X):e9666. |
| APA | Han HL.,Dong ZF.,Jia YF.,Mao RR.,Zhou QX.,...&Cao J[*].(2015).Opioid addiction and withdrawal differentially drive long-term depression of inhibitory synaptic transmission in the hippocampus.SCIENTIFIC REPORTS,5(X),e9666. |
| MLA | Han HL,et al."Opioid addiction and withdrawal differentially drive long-term depression of inhibitory synaptic transmission in the hippocampus".SCIENTIFIC REPORTS 5.X(2015):e9666. |
入库方式： OAI收割
来源：昆明动物研究所
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