NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats
文献类型：期刊论文
| 作者 | Zhou H1,2; Yu CL1,2; Wang LP2; Yang YX2; Mao RR2; Zhou QX[*]2; Xu L[*]1,2,3 |
| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
 |
| 出版日期 | 2015 |
| 卷号 | 135期号:X页码:40-45 |
| 关键词 | Anxiety Elevated plus maze One-trial tolerance Glutamatergic system Dopaminergic system |
| 通讯作者 | qixin_zhou@126.com ; lxu@vip.163.com |
| 合作状况 | 其它 |
| 英文摘要 | The elevated plus maze (EPM) test is used to examine anxiety-like behaviors in rodents. One interesting phenomenon in the EPM test is one-trial tolerance (OTT), which refers to the reduction in the anxiolylic-like effects of benzodiazepines when rodents are re-exposed to the EPM. However, the underlying mechanism of OTT is still unclear. In this study, we reported that OTT occurred when re-exposure to the EPM (trial 2) only depended on the prior experience of the EPM (trial 1) rather than diazepam treatment. This process was memory-dependent, as it was prevented by the N-methyl-D-aspartate (NMDA) receptors antagonist MK-801 1.5 h before trial 2. In addition, OTT was maintained for at least one week but was partially abolished after an interval of 28 days. Furthermore, the administration of the D1-like receptors agonist SKF38393 to the bilateral dorsal hippocampus largely prevented OTT, as demonstrated by the ability of the diazepam treatment to produce significant anxiolytic-like effects in trial 2 after a one-day interval. These findings suggest that OTT to the EPM test may occur via the activation of NMDA receptors and the inactivation of D1-like receptors in certain brain regions, including the hippocampus. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China from the Ministry of Science and Technology of China (2013CB835103 to L.X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002 to L.X.), and the National Science Foundation of China (81171294 to Y.-X.Y., 31100775 and 31371141 to Q.-X. Z.) and Science |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9318]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China 2.Laboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, CAS, Kunming 650223, China 3.CAS Center for Excellence in Brain Science, 320 Yue Yang Road, Shanghai 200031, China |
| 推荐引用方式 GB/T 7714 | Zhou H,Yu CL,Wang LP,et al. NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2015,135(X):40-45. |
| APA | Zhou H.,Yu CL.,Wang LP.,Yang YX.,Mao RR.,...&Xu L[*].(2015).NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,135(X),40-45. |
| MLA | Zhou H,et al."NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 135.X(2015):40-45. |
入库方式： OAI收割
来源：昆明动物研究所
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