Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory
文献类型：期刊论文
| 作者 | Jiang LZ1,6; Mao RR2; Zhou QX2; Yang YX2; Cao J2; Ding YQ3; Yang Y4; Zhang X5; Li LJ[*]1; Xu L[*]2 |
| 刊名 | MOLECULAR NEUROBIOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 53期号:2页码:1247-1253 |
| 关键词 | Contextual fear memory Forgetting GTPase Rac1 Hippocampus Hypermnesia |
| 通讯作者 | llj2920@163.com ; lxu@vip.163.com |
| 英文摘要 | Fear is crucial for survival, whereas hypermnesia of fear can be detrimental. Inhibition of the Rac GTPase is recently reported to impair the forgetting of initially acquired memory in Drosophila. Here, we investigated whether inhibition of Rac1 activity in rat hippocampus could contribute to the hypermnesia of contextual fear. We found that spaced but not massed training of contextual fear conditioning caused inhibition of Rac1 activity in the hippocampus and heightened contextual fear. Furthermore, intrahippocampal injection of the Rac1 inhibitor NSC23766 heightened contextual fear in massed training, while Rac1 activator CN04-A weakened contextual fear in spaced training rats. Our study firstly demonstrates that contextual fear memory in rats is actively regulated by Rac1 activity in the hippocampus, which suggests that the forgetting impairment of traumatic events in posttraumatic stress disorder may be contributed to the pathological inhibition of Rac1 activity in the hippocampus. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China (2013CB835103 and 2009CB918303), Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (31100786, 30860089, 930830046, 81171286, 91232714, 81460216, U1032605, and U1132602), and Science and Technology Program of YunnanProvince(2013GA003and2013FA048).Therearenocompeting financial interests in relation to the work. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9455]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Mental Health Institute, The 2nd Xiangya Hospital, Key Lab of Psychiatry and Mental Health of Hunan Province, Central South University, 132 Ren-Ming Road, Changsha 410011, China 2.Key Lab of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, The Chinese Academy of Sciences, 32 Jiao-Chang Dong Road, Kunming 650223, China 3.Key Laboratory of Arrhythmias, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai 200092, China 4.Department of Physiology, Kunming Medical University, Kunming 650031, China 5.Institute of Mental Health Research and Departments of Psychiatry and Cellular & Molecular Medicine, University of Ottawa, 1145 Carling Ave, Ottawa, Ontario K1Z 7K4, Canada 6.Neurology, Kunming Affiliated Hospital of Dali University, Kunming 650011, China |
| 推荐引用方式 GB/T 7714 | Jiang LZ,Mao RR,Zhou QX,et al. Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory[J]. MOLECULAR NEUROBIOLOGY,2016,53(2):1247-1253. |
| APA | Jiang LZ.,Mao RR.,Zhou QX.,Yang YX.,Cao J.,...&Xu L[*].(2016).Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory.MOLECULAR NEUROBIOLOGY,53(2),1247-1253. |
| MLA | Jiang LZ,et al."Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory".MOLECULAR NEUROBIOLOGY 53.2(2016):1247-1253. |
入库方式： OAI收割
来源：昆明动物研究所
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