Complement factor H and susceptibility to major depressive disorder in Han Chinese
文献类型：期刊论文
| 作者 | Zhang C1,2; Zhang D2; Wu ZG1; Peng DH1; Chen J1; Ni JL3; Tang WX4; Xu L2,5; Yao YG[*]2,5; Fang YR[*]1 |
| 刊名 | BRITISH JOURNAL OF PSYCHIATRY
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| 出版日期 | 2016 |
| 卷号 | 208期号:5页码:446-452 |
| 通讯作者 | yirufang@aliyun.com yaoyg@mail.kiz.ac.cn. |
| 合作状况 | 其它 |
| 英文摘要 | Background Accumulating evidence suggests that altered immunity contributes to the development of major depressive disorder (MDD). Aims To examine whether complement factor H (CFH), a regulator of activation of the alternative pathway of the complement cascade, confers susceptibility to MDD. Method Expression analyses were tested in 53 unmedicated people with MDD and 55 healthy controls. A two-stage genetic association analysis was performed in 3323 Han Chinese with or without MDD. Potential associations between CFH single nucleotide polymorphisms and age at MDD onset were evaluated. Results CFH levels were significantly lower in the MDD group at both protein and mRNA levels (P=0.009 and P=0.014 respectively). A regulatory variant in the CFH gene, rs1061170, showed statistically significant genotypic and allelic differences between the MDD and control groups (genotypic P=0.0005, allelic P=0.0001). Kaplan-Meier survival analysis showed that age at onset of MDD was significantly associated with the C allele of rs1061170 (log rank statistic chi(2)=6.82, P=0.009). The C-allele carriers had a younger age at onset of MDD (22.2 years, s.d.=4.0) than those without the C allele (23.6 years, s.d.=4.3). Conclusions CFH is likely to play an important role in the development of MDD. rs1061170 has an important effect on age at onset of MDD in Han Chinese and may therefore be related to early pathogenesis of MDD, although further study is needed. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (91232719 and 81471358), the ‘12th Five-year Plan’ of National Key Technologies R&D Program (2012BAI01B04), the 973 program from the Ministry of Science and Technology of China (2013CB835103), the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02020003) and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH, 2011-873). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9568]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Div Mood Disorders, Shanghai Mental Hlth Ctr, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China 2.Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming, Yunnan, Peoples R China 3.Tongde Hosp Zhejiang Prov, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China 4.Hangzhou Seventh Peoples Hosp, Hangzhou, Zhejiang, Peoples R China 5.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang C,Zhang D,Wu ZG,et al. Complement factor H and susceptibility to major depressive disorder in Han Chinese[J]. BRITISH JOURNAL OF PSYCHIATRY,2016,208(5):446-452. |
| APA | Zhang C.,Zhang D.,Wu ZG.,Peng DH.,Chen J.,...&Fang YR[*].(2016).Complement factor H and susceptibility to major depressive disorder in Han Chinese.BRITISH JOURNAL OF PSYCHIATRY,208(5),446-452. |
| MLA | Zhang C,et al."Complement factor H and susceptibility to major depressive disorder in Han Chinese".BRITISH JOURNAL OF PSYCHIATRY 208.5(2016):446-452. |
入库方式： OAI收割
来源：昆明动物研究所
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