Brain volume alteration and the correlations with the clinical characteristics in drug-naive first-episode MDD patients: A voxel-based morphometry study
文献类型：期刊论文
| 作者 | Cheng YQ1,2,3; Xu JA4; Yang T3; Li L5; Shan BC5; Xu XF[*]3; Xu L[*]1,2; Chai P5; Li HJ6; Luo CR6 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 480期号:1页码:30-34 |
| 关键词 | Major depressive disorder First episode Neuroimaging Drug-naive Adult-onset |
| 通讯作者 | xfxu2004@sina.com ; lxu@vip.163.com |
| 合作状况 | 其它 |
| 英文摘要 | Structural brain abnormalities have been widely reported in major depressive disorder (MDD). However, many previous results cannot exclude the interferences of medication or multiple recurrent episodes. In this study, we examined structural brain abnormalities by comparing 68 drug-naive first-episode adult-onset MDD and 68 healthy controls (HCs). Structural magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) methods were used. The mean values of grey matter volume/white matter volume (GMV/WMV) were calculated, then the differences between MDD and HCs were analyzed, and the associations of the differences with clinical characteristics of depression were discussed. The whole brain GMV/WMV did not differ between MDD patients and HCs; however, the regional GMV of the right pre-supplementary motor area (pre-SMA) was smaller in MDD patients. The GMV of both hippocampi was positively correlated with symptom severity and lower in patients with long durations. These results indicate the GMV reduction of the pre-SMA at an early stage of depression, whereas the GMV of the hippocampus is associated with depressive characteristics. Moreover, the whole brain GMV/WMV was negatively related to the duration of depression, supporting that volume loss could become progressive during the development of disease. These results may suggest the importance of identifying and intervening depression at an early stage, especially the first year after onset, to prevent volume loss in the brain. |
| 资助信息 | This work is supported by grants from the National Natural Science Foundation of China (30530250 and 30500150), Sci- ence and Technology Foundation of Yunnan Province (2006PT08), 973 Program from the Ministry of Science and Technology of China (2006CB500808, 2009CB941300, 2007CB512303 and 2009CB522006), United Funding of Yunnan Provincial Science and Technology Department and Kunming Medical College (2008C0005R), and Funding of Health Science and Technology Plan of Yunnan Province (2009NS092). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9607]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Graduate School of Chinese Academy of Sciences, Beijing 100039, China 3.Department of Psychiatry, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650031, China 4.Department of Internal Medicine, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650031, China 5.Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China 6.Department of Magnetic Resonance Imaging, The First Hospital of Kunming City, Kunming, Yunnan 650031, China |
| 推荐引用方式 GB/T 7714 | Cheng YQ,Xu JA,Yang T,et al. Brain volume alteration and the correlations with the clinical characteristics in drug-naive first-episode MDD patients: A voxel-based morphometry study[J]. NEUROSCIENCE LETTERS,2010,480(1):30-34. |
| APA | Cheng YQ.,Xu JA.,Yang T.,Li L.,Shan BC.,...&Luo CR.(2010).Brain volume alteration and the correlations with the clinical characteristics in drug-naive first-episode MDD patients: A voxel-based morphometry study.NEUROSCIENCE LETTERS,480(1),30-34. |
| MLA | Cheng YQ,et al."Brain volume alteration and the correlations with the clinical characteristics in drug-naive first-episode MDD patients: A voxel-based morphometry study".NEUROSCIENCE LETTERS 480.1(2010):30-34. |
入库方式： OAI收割
来源：昆明动物研究所
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