Corticosterone regulates fear memory via Rac1 activity in the hippocampus
文献类型：期刊论文
| 作者 | Gan P1,2,3; Ding ZY3; Xu L3,4; Zhou QX[*]3; Gan C5; Mao RR3; Zhou H3 |
| 刊名 | Psychoneuroendocrinology
 |
| 出版日期 | 2016 |
| 卷号 | 71期号:X页码:86-93 |
| 关键词 | Corticosterone Fear memory Foot shocks Hippocampus Rac1-GTP Stress |
| 通讯作者 | quxin zhou@126.com, ganping yeow@hotmail.com |
| 中文摘要 | Stressful events can generate enduring memories, which may induce certain psychiatric disorders such as post-traumatic stress disorder (PTSD). However, the underlying molecular mechanisms in these processes remain unclear. In this study, we examined whether the active form of the small G protein Rac1, Rac1-GTP, is involved in fear memory. Firstly, we detected the time course changes of Rac1-GTP after foot shocks (a strong stressor) and exogenous corticosterone (CORT) treatment. The data showed that stress and CORT induced the downregulation of Rac1-GTP in the hippocampus. Changes in the serum CORT level were negatively correlated with the level of Rac1-GTP. Additionally, a glucocorticoid receptor antagonist, RU38486, not only recovered the expression of Rac1-GTP but also impaired fear memory. Furthermore, systemic administration of NSC23766, an inhibitor of Rac1-GTP, improved fear memory at 1.5 and 24h. Therefore, Rac1 activity plays a critical role in stress-related cognition and may be a potential target in stress-related disorders. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by the 973 program from the Min- istry of Science and Technology of China (2013CB835103 to L.X.), an NSFC-CIHR joint grant (81161120536 to L.X.), The National Science Foundation of China (31100775 and 31371141 to Q-X.Z., 81171294 to Y-Y. X.), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002) and Science and Technology Program of Yunnan Province (2013GA003). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9959]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.College of Life Sciences, Yunnan University, China 2.College of Basic Medicine, Kunming Medical University, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, and Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China 4.CAS Center for Excellence in Brain Science, 320 Yue Yang Road, Shanghai, 200031, China 5.Endocrinology Department, Second Affiliated Hospital, Kunming Medical University, Kunming, China |
| 推荐引用方式 GB/T 7714 | Gan P,Ding ZY,Xu L,et al. Corticosterone regulates fear memory via Rac1 activity in the hippocampus[J]. Psychoneuroendocrinology,2016,71(X):86-93. |
| APA | Gan P.,Ding ZY.,Xu L.,Zhou QX[*].,Gan C.,...&Zhou H.(2016).Corticosterone regulates fear memory via Rac1 activity in the hippocampus.Psychoneuroendocrinology,71(X),86-93. |
| MLA | Gan P,et al."Corticosterone regulates fear memory via Rac1 activity in the hippocampus".Psychoneuroendocrinology 71.X(2016):86-93. |
入库方式： OAI收割
来源：昆明动物研究所
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