Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear
文献类型：期刊论文
| 作者 | Jiang LZ1,2,6; Mao RR2; Zhou QX2; Yang YX2; Wang LP2; Li LJ[*]4; Xu L[*]2,4,5; Tong JB3; Li JN2; Chai AP2 |
| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 109期号:X页码:216-222 |
| 关键词 | Rac1 activity Hippocampus Extinction Contextual fear memory |
| 通讯作者 | llj2920@163.com ; lxu@vip.163.com |
| 英文摘要 | Promoting extinction of fear memory is the main treatment of fear disorders, especially post-traumatic stress disorder (PTSD). However, fear extinction is often incomplete in these patients. Our previous study had shown that Rac1 activity in hippocampus plays a crucial role in the learning of contextual fear memory in rats. Here, we further investigated whether Rac1 activity also modulated the extinction of contextual fear memory. We found that massed extinction obviously upregulated hippocampal Rac1 activity and induced long-term extinction of contextual fear in rats. Intrahippocampal injection of the Rac1 inhibitor NSC23766 prevents extinction of contextual fear in massed extinction training rats. In contrast, long-spaced extinction downregulated Rac1 activity and caused less extinction. And Rac1 activator CN04-A promotes extinction of contextual fear in long-spaced extinction rats. Our study demonstrates that inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear, suggesting that modulating Rac1 activity of the hippocampus may be promising therapy of fear disorders. |
| 资助信息 | This work was supported by National Basic Research Program of China (2013CB835103, 2009CB918303), and Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (930830046, 81171286, 81171294, 91232714, 81460216, U1032605 and U1132602), Science and Technology Program of Yunnan Province (2013GA003 and 2013FA048), Scientific research start-up capital to doctor in Dali University (KYD201422), Reserve Personnel Training Plan Project of Middle-aged and Young Academic and Technical Leaders of Yunnan Province (2015HB054), China Postdoctoral Science Foundation funded project (2016M592725). There are not any competing financial interests in relation to the work. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10232]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Department of Neurology, Kunming Affiliated Hospital of Dali University, Kunming, 650011, China 2.Key Lab of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, 650223, China 3.The Third Xiangya Hospital, Central South University, Changsha, 410013, China 4.Mental Health Institute, The 2nd Xiangya Hospital, and Key Lab of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, 410011, China 5.University of the Chinese Academy of Sciences, Beijing, 100049, China 6.Department of Neuropsychopathy, Clinical Medical School, Dali University, Dali, 671000, China |
| 推荐引用方式 GB/T 7714 | Jiang LZ,Mao RR,Zhou QX,et al. Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear[J]. NEUROPHARMACOLOGY,2016,109(X):216-222. |
| APA | Jiang LZ.,Mao RR.,Zhou QX.,Yang YX.,Wang LP.,...&Chai AP.(2016).Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear.NEUROPHARMACOLOGY,109(X),216-222. |
| MLA | Jiang LZ,et al."Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear".NEUROPHARMACOLOGY 109.X(2016):216-222. |
入库方式： OAI收割
来源：昆明动物研究所
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