Reducing central serotonin in adulthood promotes hippocampal neurogenesis
文献类型：期刊论文
| 作者 | Song NN1,2; Jia YF3,4; Liu XZ1,2; Hu L1,2; Lan W1,2,5; Chen L1,2,3; Lesch KP6; Chen XY7; Zhang L1,2; Xu L[*]3,4 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:X页码:e20338 |
| 通讯作者 | lxu@vip.163.com ; dingyuqiang@vip.163.com |
| 英文摘要 | Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We used tamoxifen (TM)-induced Cre in Pet1-CreERT2 mice to either deplete central serotonergic (5-HTergic) neurons or inactivate 5-HT synthesis in adulthood and explore the role of central 5-HT in adult hippocampal neurogenesis. A dramatic increase in hippocampal neurogenesis is present in these two central 5-HT-deficient mice and it is largely prevented by administration of agonist for 5-HTR2c receptor. In addition, the survival of new-born neurons in the hippocampus is enhanced. Furthermore, the adult 5-HT-deficient mice showed reduced depression-like behaviors but enhanced contextual fear memory. These findings demonstrate that lowering central 5-HT function in adulthood can also enhance adult hippocampal neurogenesis, thus revealing a new aspect of central 5-HT in regulating adult neurogenesis. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the Ministry of Science and Technology of China (2013CB835100, 2012CB966900, 2011CB510000, 2012AA022402), the National Natural Science Foundation of China (81571332, 81221001, 31100788, 81200933, 81200692, 81101026, 91232724), Science and Technology Commission of Shanghai Municipality (12XD1404800), and the Fundamental Research Funds for the Central Universities (2013KJ049). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10320]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Arrhythmias, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai, China 2.Department of Anatomy and Neurobiology, Collaborative Innovation Center for Brain Science, Tongji University School of Medicine, Shanghai, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 4.Graduate University of the Chinese Academy of Sciences, Beijing, China 5.Department of Human Anatomy, Guangxi Medical University, Nanning, Guangxi, China 6.Division of Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany 7.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Song NN,Jia YF,Liu XZ,et al. Reducing central serotonin in adulthood promotes hippocampal neurogenesis[J]. SCIENTIFIC REPORTS,2016,6(X):e20338. |
| APA | Song NN.,Jia YF.,Liu XZ.,Hu L.,Lan W.,...&Huang Y.(2016).Reducing central serotonin in adulthood promotes hippocampal neurogenesis.SCIENTIFIC REPORTS,6(X),e20338. |
| MLA | Song NN,et al."Reducing central serotonin in adulthood promotes hippocampal neurogenesis".SCIENTIFIC REPORTS 6.X(2016):e20338. |
入库方式： OAI收割
来源：昆明动物研究所
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