Requirement for the Endocannabinoid System in Social Interaction Impairment Induced by Coactivation of Dopamine D1 and D2 Receptors in the Piriform Cortex
文献类型：期刊论文
| 作者 | Zenko M1; Zhu YY2; Zhang X[*]1; Dremencov E1; Ren W3; Xu L2 |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 89期号:8页码:1245-1258 |
| 关键词 | cannabinoid receptor dopamine receptor social interaction |
| 通讯作者 | xia.zhang@rohcg.on.ca |
| 合作状况 | 其它 |
| 英文摘要 | The dopamine receptor family consists of D1-D5 receptors (D1R-D5R), and we explored the contributions of each dopamine receptor subtype in the piriform cortex (PirC) to social interaction impairment (SII). Rats received behavioral tests or electrophysiological recording of PirC neuronal activity after injection of the D1R/D5R agonist SKF38393, the D2R/D3R/D4R agonist quinpirole, or both, with or without pretreatment with dopamine receptor antagonists, D1R or D5R antisense oligonucleotides, the cannabinoid CB1 receptor antagonist AM281, or the endocannabinoid transporter inhibitor VDM11. Systemic injection of SKF38393 and quinpirole together, but not each one alone, induced SII and increased PirC firing rate, which were blocked by D1R or D2R antagonist. Intra-PirC microinfusion of SKF38393 and quinpirole together, but not each one alone, also induced SII, which was blocked by D1R antisense oligonucleotides or D2R antagonist but not by D3R or D4R antagonist or D5R antisense oligonucleotides. SII induced by intra-PirC SKF38393/quinpirole was blocked by AM281 and enhanced by VDM11, whereas neither AM281 nor VDM11 alone affected social interaction behavior. Coadministration of SKF38393 and quinpirole produced anxiolytic effects without significant effects on locomotor activity, olfaction, and acquisition of olfactory short-term memory. These findings suggest that SII induced by coactivation of PirC D1R and D2R requires the endocannabinoid system. |
| 资助信息 | Contract grant sponsor: Canadian Institutes of Health Research (to X.Z.); Contract grant sponsor: Chinese Education Ministry (to X.Z.); Contract grant sponsor: National Natural Science Foundation of China (to L.X.). |
| 源URL | [http://159.226.149.26:8080/handle/152453/10415]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Institute of Mental Health Research and Departments of Psychiatry and Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, People’s Republic of China 3.School of Life Sciences, Shaanxi Normal University, Xian, Shaanxi Province, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Zenko M,Zhu YY,Zhang X[*],et al. Requirement for the Endocannabinoid System in Social Interaction Impairment Induced by Coactivation of Dopamine D1 and D2 Receptors in the Piriform Cortex[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2011,89(8):1245-1258. |
| APA | Zenko M,Zhu YY,Zhang X[*],Dremencov E,Ren W,&Xu L.(2011).Requirement for the Endocannabinoid System in Social Interaction Impairment Induced by Coactivation of Dopamine D1 and D2 Receptors in the Piriform Cortex.JOURNAL OF NEUROSCIENCE RESEARCH,89(8),1245-1258. |
| MLA | Zenko M,et al."Requirement for the Endocannabinoid System in Social Interaction Impairment Induced by Coactivation of Dopamine D1 and D2 Receptors in the Piriform Cortex".JOURNAL OF NEUROSCIENCE RESEARCH 89.8(2011):1245-1258. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。