White Matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder
文献类型：期刊论文
| 作者 | Ma N; Li LJ*; He Z; Li ZX; Tan LW; Stone WS; Zhang ZS; Xu L; Shu N; Liu J |
| 刊名 | AMERICAN JOURNAL OF PSYCHIATRY
 |
| 出版日期 | 2007 |
| 卷号 | 164期号:5页码:823-826 |
| 通讯作者 | 13807314575@hnmcc.com |
| 合作状况 | 其它 |
| 英文摘要 | Objective: The aim of this study was to explore the microstructural integrity of whole-brain white matter by diffusion tensor imaging in first-episode, treatment-naive young adults with major depressive disorder. Method: Diffusion tensor imaging scans were obtained from 14 first-episode, treatment-naive young adult patients with major depressive disorder and 14 healthy comparison subjects. A voxel-based method was used to analyze the scans. Results: The patient group exhibited significantly lower fractional anisotropy values than healthy comparison subjects in the white matter of the right middle frontal gyrus, the left lateral occipitotemporal gyrus, and the subgyral and angular gyri of the right parietal lobe. There were no regions of significantly higher fractional anisotropy values in patients compared with healthy comparison subjects. Conclusions: These findings suggest that abnormalities of brain white matter may be present early in the course of major depressive disorder. They also support the idea that white matter lesions may disrupt the neural circuits involved in mood regulation and thus contribute to the neuropathology of major depressive disorder. |
| 资助信息 | Supported by grants from National Natural Science Foundation of China (30670751 and 30470621 to Lingjiang Li, 30570509 and 30425004 to Tianzi Jiang), 973 Program (2006CB500800 to Lingjiang Li and Lin Xu), and a grant from the National Ministry of Education of China (20030533022 to Lingjiang Li). The authors thank Yi H. Hao, of the Mental Health Institute of the 2nd Xiangya Hospital, Central South University, for assistance in illustration processing and Yu H. Xie, of Duck University, for assistance in composition. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10535]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 推荐引用方式 GB/T 7714 | Ma N,Li LJ*,He Z,et al. White Matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder[J]. AMERICAN JOURNAL OF PSYCHIATRY,2007,164(5):823-826. |
| APA | Ma N.,Li LJ*.,He Z.,Li ZX.,Tan LW.,...&Gong GL.(2007).White Matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder.AMERICAN JOURNAL OF PSYCHIATRY,164(5),823-826. |
| MLA | Ma N,et al."White Matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder".AMERICAN JOURNAL OF PSYCHIATRY 164.5(2007):823-826. |
入库方式： OAI收割
来源：昆明动物研究所
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