Magnetic resonance imaging a magnetic resonance spectroscopy study of deficits in hippocampal structure in fire victims with recent-onset posttraumatic stress disorder
文献类型：期刊论文
| 作者 | Li LJ1; Chen SL[*]1,3; Liu J2; Zhang JL1; Xu L1,4 |
| 刊名 | CANADIAN JOURNAL OF PSYCHIATRY
 |
| 出版日期 | 2006 |
| 卷号 | 51期号:7页码:431-437 |
| 关键词 | hippocampus posttraumatic stress disorder magnetic resonance imaging magnetic resonance spectroscopy |
| 通讯作者 | shulinchen1990@yahoo.com.cn |
| 合作状况 | 其它 |
| 英文摘要 | Objective: To explore hippocampal structural abnormalities in fire victims with recent-onset posttraumatic stress disorder (PTSD). Method: We compared 12 patients with recent-onset PTSD diagnosed according to DSM-IV criteria 6 to 8 months after a major fire with 12 individuals without PTSD who were victims of the same fire accident. Voxel-based morphometry (VBM) and magnetic resonance spectroscopy (MRS) were combined to examine hippocampal structural abnormalities in patients with recent-onset PTSD. Results: Results of VBM showed that the grey matter density of the left hippocampus was lower in the group with PTSD than it was in the group without PTSD. Results of MRS showed that the ratio of N-acetyl asparate and creatine in the left hippocampus was significantly lower in patients with PTSD than in control subjects. Conclusion: Patients with recent-onset PTSD had hippocampal structural abnormalities. |
| 资助信息 | This work was supported by a grant (30470621) from the National Natural Science Foundation of China, a grant (2006CB5000808) from the National 973 Program of China, and a grant (20030533022) from the National Ministry of Education of China. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10577]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Mental Health Institute, The Second Xiangya Hospital, Central South University Changsha, Hunan, China 2.Department of Radiation, The Second Xiangya Hospital, Central South University Changsha, Hunan, China 3.Department of Clinical Psychology, The Seventh Hospital of Hang Zhou, Hangzhou, Zhejiang, China. 4.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunan, China |
| 推荐引用方式 GB/T 7714 | Li LJ,Chen SL[*],Liu J,et al. Magnetic resonance imaging a magnetic resonance spectroscopy study of deficits in hippocampal structure in fire victims with recent-onset posttraumatic stress disorder[J]. CANADIAN JOURNAL OF PSYCHIATRY,2006,51(7):431-437. |
| APA | Li LJ,Chen SL[*],Liu J,Zhang JL,&Xu L.(2006).Magnetic resonance imaging a magnetic resonance spectroscopy study of deficits in hippocampal structure in fire victims with recent-onset posttraumatic stress disorder.CANADIAN JOURNAL OF PSYCHIATRY,51(7),431-437. |
| MLA | Li LJ,et al."Magnetic resonance imaging a magnetic resonance spectroscopy study of deficits in hippocampal structure in fire victims with recent-onset posttraumatic stress disorder".CANADIAN JOURNAL OF PSYCHIATRY 51.7(2006):431-437. |
入库方式： OAI收割
来源：昆明动物研究所
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