Acute low-dose melamine affects hippocampal synaptic plasticity and behavior in rats
文献类型：期刊论文
| 作者 | Yang Y1,2,5; Xiong GJ2,3; Xu L[*]1,2; Mao RR[*]2; Yu DF1,4; Cao J2; Wang LP2 |
| 刊名 | TOXICOLOGY LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 214期号:1页码:63-68 |
| 关键词 | Melamine Hippocampus Synaptic plasticity Immobility time Locomotor activity |
| 通讯作者 | lxu@vip.163.com ; talktomaomao@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Foods contaminated with melamine potentially cause risk to human health. However, the neurotoxicity of melamine has not been adequately assessed. Here, we aimed to examine the effects of acute low-dose exposure to melamine on hippocampal synaptic plasticity and behaviors in rats. We found that bath application of 50-500 mu g/ml melamine decreased basal synaptic transmission in the Schaffer collateral-CA1 pathway of hippocampal slices from postnatal days (P) 10-14 rats in a concentration-dependent manner; furthermore, this decrease in transmission was related to the reduction of presynaptic function as indicated by the increased paired-pulse facilitation ratio. Rats at 2-3 months old were less vulnerable to the effects of 500 mu g/ml melamine on basal synaptic transmission when compared with P10-14 and P21-28 rats. Melamine (50 mu g/ml) significantly impaired long-term potentiation (LTP), without affecting long-term depression (LTD), in both P10-14 and 2-3 month-old rats. Oral treatment with melamine (5 and 25 mg/kg) 1 h before behavioral tests significantly decreased the immobility time of the forced swim test in 2-3 month-old rats and had no effect on locomotor activity in the open field test in both P21-28 and 2-3 month-old rats. Our findings reveal some of the aspects of neurotoxicity induced by acute low-dose of melamine in hippocampal synaptic plasticity and behavior. (c) 2012 Elsevier Ireland Ltd. All rights reserved. |
| 资助信息 | We would like to thank the National Natural Science Foun- dation of China (U1032605, 31070962 and 31100786) and the National Basic Research Program of China (2009CB522006 and 2009CB941302) for their financial support. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10813]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.School of Life Sciences, Yunnan University, Kunming 650021, PR China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 3.Graduate University of Chinese Academy Sciences, Beijing 100039, PR China 4.Department of Nuclear Medicine, First People’s Hospital of Yunnan Province, Kunming 650032, PR China 5.Department of Physiology, Kunming Medical University, Kunming 650500, PR China |
| 推荐引用方式 GB/T 7714 | Yang Y,Xiong GJ,Xu L[*],et al. Acute low-dose melamine affects hippocampal synaptic plasticity and behavior in rats[J]. TOXICOLOGY LETTERS,2012,214(1):63-68. |
| APA | Yang Y.,Xiong GJ.,Xu L[*].,Mao RR[*].,Yu DF.,...&Wang LP.(2012).Acute low-dose melamine affects hippocampal synaptic plasticity and behavior in rats.TOXICOLOGY LETTERS,214(1),63-68. |
| MLA | Yang Y,et al."Acute low-dose melamine affects hippocampal synaptic plasticity and behavior in rats".TOXICOLOGY LETTERS 214.1(2012):63-68. |
入库方式： OAI收割
来源：昆明动物研究所
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