Opioid Withdrawal for 4 Days Prevents Synaptic Depression Induced by Low Dose of Morphine or Naloxone in Rat Hippocampal CA1 Area In Vivo
文献类型：期刊论文
| 作者 | Dong ZF1,2,3; Han HL1,2,3; Cao J[*]1,2,3; Xu L[*]1,2,3,4 |
| 刊名 | HIPPOCAMPUS
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:2页码:335-343 |
| 关键词 | withdrawal synaptic depression hippocampus stress glucocorticoid receptor (GR) |
| 通讯作者 | juncao@vip.163.com ; lxu@vip.163.com |
| 英文摘要 | The formation of memory is believed to depend on experience- or activity-dependent synaptic plasticity, which is exquisitely sensitive to psychological stress since inescapable stress impairs long-term potentiation (LTP) but facilitates long-term depression (LTD). Our recent studies demonstrated that 4 days of opioid withdrawal enables maximal extents of both hippocampal LTP and drug-reinforced behavior; while elevated-platform stress enables these phenomena at 18 h of opioid withdrawal. Here, we examined the effects of low dose of morphine (0.5 mg kg(-1), i.p.) or the opioid receptor antagonist naloxone (1 mg kg(-1), i.p.) on synaptic efficacy in the hippocampal CA1 region of anesthetized rats. A form of synaptic depression was induced by low dose of morphine or naloxone in rats after 18 h but not 4 days of opioid withdrawal. This synaptic depression was dependent on both N-methyl-D-aspartate receptor and synaptic activity, similar to the hippocampal long-term depression induced by low frequency stimulation. Elevated-platform stress given 2 h before experiment prevented the synaptic depression at 18 h of opioid withdrawal; in contrast, the glucocorticoid receptor (GR) antagonist RU38486 treatment (20 mg kg(-1), s.c., twice per day for first 3 days of withdrawal), or a high dose of morphine reexposure (15 mg kg(-1), s.c., 12 h before experiment), enabled the synaptic depression on 4 days of opioid withdrawal. This temporal shift of synaptic depression by stress or GR blockade supplements our previous findings of potentially correlated temporal shifts of LTP induction and drug-reinforced behavior during opioid withdrawal. Our results therefore support the idea that stress experience during opioid withdrawal may modify hippocampal synaptic plasticity and play important roles in drug-associated memory. (C) 2009 Wiley-Liss, Inc. |
| 收录类别 | SCI |
| 资助信息 | The National Natural Science Foundation of China; Grant number: 30530250; Grant sponsor: The National Basic Research Pro- gram; Grant number: 973; Grant sponsor: Basic Research Program of the Ministry of Science and Technology of China; Grant numbers: 2006CB500808, 2007CB512303, 2009CB522006. |
| 源URL | [http://159.226.149.26:8080/handle/152453/10844]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming, People’s Republic of China 2.Centre for Bioresource and Common Disease Research, Kunming Institute of Zoology, CAS, Kunm- ing, People’s Republic of China 3.Graduate School of the Chinese Acad- emy of Sciences, Beijing, People’s Republic of China 4.Mental Health Institute, The 2nd Hospital of Xiangya Medical College, Central South University, Changsha, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Dong ZF,Han HL,Cao J[*],et al. Opioid Withdrawal for 4 Days Prevents Synaptic Depression Induced by Low Dose of Morphine or Naloxone in Rat Hippocampal CA1 Area In Vivo[J]. HIPPOCAMPUS,2010,20(2):335-343. |
| APA | Dong ZF,Han HL,Cao J[*],&Xu L[*].(2010).Opioid Withdrawal for 4 Days Prevents Synaptic Depression Induced by Low Dose of Morphine or Naloxone in Rat Hippocampal CA1 Area In Vivo.HIPPOCAMPUS,20(2),335-343. |
| MLA | Dong ZF,et al."Opioid Withdrawal for 4 Days Prevents Synaptic Depression Induced by Low Dose of Morphine or Naloxone in Rat Hippocampal CA1 Area In Vivo".HIPPOCAMPUS 20.2(2010):335-343. |
入库方式： OAI收割
来源：昆明动物研究所
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