Stress within the postseizure time window inhibits seizure recurrence
文献类型：期刊论文
| 作者 | Zhou QX1,3; Mao RR1; Cao J[*]1; Xu L[*]1,4; Duan TT2; Tan JW1,3; Tian M1,3 |
| 刊名 | EPILEPSY & BEHAVIOR
 |
| 出版日期 | 2010 |
| 卷号 | 18期号:3页码:201–206 |
| 关键词 | Seizure recurrence Corticosterone Mineralocorticoid receptors Glucocorticoid receptors Pentylenetetrazole Kindling model Epilepsy Stress |
| 通讯作者 | juncao@vip.163.com ; lxu@vip.163.com |
| 英文摘要 | Recurrence is a key characteristic in the development of epilepsy. It remains unclear whether seizure recurrence is sensitive to postseizure stress. Here, tonic-clonic seizures were induced with a convulsive dose of pentylenetetrazole (PTZ), and acute seizure recurrence was evoked with a subconvulsive dose of the drug. We found that stress inhibited seizure recurrence when applied 30 minutes or 2 hours, but not 4 hours, after the tonic-clonic seizure. The time-dependent anti-recurrence effect of stress was mimicked by the stress hormone corticosterone and blocked by co-administration of mineralocorticoid and glucocorticoid receptor antagonists. Furthermore, in a PTZ-induced epileptic kindling model, corticosterone administered 30 minutes after each seizure decreased the extent of seizures both during the kindling establishment and in the following challenge test. These results provide novel insights into both the mechanisms of and therapeutic strategies for epilepsy. |
| 收录类别 | SCI |
| 资助信息 | This work is supportedby grants fromthe National Natural Science Foundation of China (30870820 to L.X. and 30870806 to J.C.), the Basic Research Program of the Ministry of Science and Technology of China (2006CB500808 and 2009CB941300 to L.X.; 2007CB512303 and 2009CB522006 to J.C.), and the Science and Technology Foundation of Yunnan Province (2006PT08 to L.X.). |
| 语种 | 德语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10845]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.School of Life Sciences, University of Science and Technology of China, Hefei, China 3.Graduate School, Chinese Academy of Sciences, Beijing, China 4.Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, China |
| 推荐引用方式 GB/T 7714 | Zhou QX,Mao RR,Cao J[*],et al. Stress within the postseizure time window inhibits seizure recurrence[J]. EPILEPSY & BEHAVIOR,2010,18(3):201–206. |
| APA | Zhou QX.,Mao RR.,Cao J[*].,Xu L[*].,Duan TT.,...&Tian M.(2010).Stress within the postseizure time window inhibits seizure recurrence.EPILEPSY & BEHAVIOR,18(3),201–206. |
| MLA | Zhou QX,et al."Stress within the postseizure time window inhibits seizure recurrence".EPILEPSY & BEHAVIOR 18.3(2010):201–206. |
入库方式： OAI收割
来源：昆明动物研究所
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