White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging
文献类型：期刊论文
| 作者 | Xu J4; Cheng YQ6; Luo CR7; Li XZ4; Li L6; Zhou QX3; Chen B1; Cao J3; Chai P6; Xu XF5 |
| 刊名 | JOURNAL OF RHEUMATOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 37期号:5页码:974-986 |
| 通讯作者 | wenjf@mail.kiz.ac.cn |
| 英文摘要 | Objective. The central nervous system (CNS) is often affected by systemic lupus erythematosus (SLE), but assessment of CNS outcomes using noninvasive cerebral structural measures remains in its infancy. Magnetic resonance imaging (MRI) with expert visual interpretation is critical to diagnosis, but does not permit quantitative measurements. Our pilot study investigated whether quantitative brain volumetric analyses could be used to detect white-matter (WM) abnormalities and responses to treatment in SLE (ClinicalTrials.gov: NCT00703742). Methods. Forty-two pairs of SLE patients and healthy controls underwent high-resolution 3-dimensional structural MRI scans. Combining voxel-based morphometry and region of interest analyses, subtle WM volume abnormalities in whole brains from SLE patients were identified, and regional WM volume was calculated. Associations between WM volume and symptom severity, as well as the effects of immunosuppressive therapy, were then investigated. Results. The WM volume of the SLE group was significantly decreased in the bilateral posterior and anterior crus of the internal capsule (PIC and AIC, respectively), the subgyral right frontal lobe, and left temporal lobe (p<0.001). Regional WM volume (left PIC and right AIC) was correlated with SLEDAI scores. The WM volume of patients treated with immunosuppressive therapy was greater than that of patients who were never treated with immunosuppressive therapy. Conclusion. Quantitative brain volumetric analyses detect brain injuries in WM for SLE that are not obvious by conventional MRI, and may be adequately sensitive and quantitative to measure the effect of therapeutic interventions M preventing brain injury and outcomes in SLE. (First Release March 15 2010; J Rheumatol 2010;37:974-86; doi:10.3899/jrheum.090967) |
| 资助信息 | Supported by grants from United Funding of Yunnan Provincial Science and Technology Department and Kunming Medical College (2008C0005R to XFX), the National Natural Science Foundation of China (30530250 to LX and 30500150 to JC), the Science and Technology Foundation of Yunnan Province (2006PT08 to LX), and the 973 Program from the Ministry of Science and Technology of China (2006CB500808 and 2009CB941300 to LX; 2007CB512303 and 2009CB522006 to JC). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10847]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_真核细胞进化基因组 昆明动物研究所_其他 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 2.Graduate School of Chinese Academy of Sciences, Beijing 3.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences, Kunming 4.Department of Rheumatology and Immunology, The First Affiliated Hospital of Kunming Medical College, Kunming 5.Department of Psychiatry, The First Affiliated Hospital of Kunming Medical College, Kunming 6.Key Laboratory of Nuclear Analysis, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 7.Magnetic Resonance Imaging Center, The First Hospital of Kunming City, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Xu J,Cheng YQ,Luo CR,et al. White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging[J]. JOURNAL OF RHEUMATOLOGY,2010,37(5):974-986. |
| APA | Xu J.,Cheng YQ.,Luo CR.,Li XZ.,Li L.,...&Li HJ.(2010).White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging.JOURNAL OF RHEUMATOLOGY,37(5),974-986. |
| MLA | Xu J,et al."White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging".JOURNAL OF RHEUMATOLOGY 37.5(2010):974-986. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。