Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory
文献类型：期刊论文
| 作者 | Mao RR1,2; Tian M1,2; Cao J[*]1,2; Yang YX1,2; Zhou QX1,2; Xu L1,2,3 |
| 刊名 | EPILEPSY & BEHAVIOR
 |
| 出版日期 | 2009 |
| 卷号 | 15期号:4页码:441-444 |
| 关键词 | Pentylenetetrazol Brief seizures Morris water maze Contextual fear conditioning Acquisition Consolidation |
| 通讯作者 | juncao@vip.163.com |
| 英文摘要 | Previous Studies have demonstrated that in the pentylenetetrazol (PTZ) kindling model, recurrent seizures either impair or have no effect on learning and memory. However, the effects of brief seizures on learning and memory remain unknown. Here, we found that a single injection of a convulsive dose of PTZ (50 mg/kg, ip) induced brief seizures in Sprague-Dawley rats. Administration of PTZ before training impaired the acquisition of spatial memory in the Morris water maze (MWM) and fear memory in contextual fear conditioning. However, the administration of PTZ immediately after training did not affect memory consolidation in either task. These findings suggest that brief seizures have different effects on acquisition and consolidation of spatial and fear memory. (C) 2009 Elsevier Inc. All rights reserved. |
| 资助信息 | This work is financially supported by the National Science Foundation of China (30870820), the 973 program of the Ministry of Science and Technology of China (2006CB500800, 2007CB512303 and 2009CB941300), and the Science and Technol- ogy Foundation of Yunnan Province (2006PT08). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10852]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 65022, People’s Republic of China 2.Graduate University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China 3.Mental Health Institute, 2nd Hospital of Central South University, Changsha 410011, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Mao RR,Tian M,Cao J[*],et al. Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory[J]. EPILEPSY & BEHAVIOR,2009,15(4):441-444. |
| APA | Mao RR,Tian M,Cao J[*],Yang YX,Zhou QX,&Xu L.(2009).Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory.EPILEPSY & BEHAVIOR,15(4),441-444. |
| MLA | Mao RR,et al."Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory".EPILEPSY & BEHAVIOR 15.4(2009):441-444. |
入库方式： OAI收割
来源：昆明动物研究所
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