Sexual Behavior Modulates Contextual Fear Memory Through Dopamine D1/D5 Receptors
文献类型：期刊论文
| 作者 | Bai HY1; Cao J2; Liu N3; Xu L2; Luo JH[*]1 |
| 刊名 | HIPPOCAMPUS
 |
| 出版日期 | 2009 |
| 卷号 | 19期号:3页码:289–298 |
| 关键词 | competition emotional memory hippocampal LTP instinctive behavior reward |
| 通讯作者 | luojianhong@zju.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Traumatic events always lead to aversive emotional memory, i.e., fear memory. In contrast, positive events in daily life such as sex experiences seem to reduce aversive memory after aversive events. Thus, we hypothesized that post-traumatic pleasurable experiences, especially instinctive behaviors such its sex, might modulate traumatic memory through a memory competition mechanism. Here, we first report that male rats persistently expressed much lower fear responses when exposed to females, but not when exposed to males, for 24 h immediately after contextual fear conditioning. Remarkably, this effect of sexual behavior was blocked by either systemic or intrahippocampal injection of the dopamine D1/D5 receptor antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5 -tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) and was mimicked by systemic but not intrahippocampal injection of the D1/D5 receptor agonist R(+)-1-phenyl-2,3,4,5-tetrahydro-1 H-3-benzazepine-7,8-diol hydrochloride (SKF39393). Furthermore, as a candidate mechanism underlying contextual fear memory, the impaired induction of hippocampal long-term potentiation (LTP) elicited by conditioned fear was rescued in male rats immediately exposed to female but not male rats for 24 h. Systemic injection of the dopamine D1/D5 receptor antagonist SCH23390 or agonist SKF38393 prevented or mimicked the effect of sexual behavior on the impaired induction of hippocampal LTP. Thus, our finding suggests that dopaminergic functions may, at least partially, govern competition between contextual fear and enjoyable memories through the modulation of hippocampal LTP. (C) 2008 Wiley-Liss, Inc. |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China; Grant numbers: 30530250, 30730038; Grant sponsor: The 973 Programs, Ministry of Science and Technology of China; Grant numbers: 2006CB500808, 2007CB512303; Grant sponsor: The Science and Technology Foundation of Yunnan Province; Grant number: 2006PT08. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10857]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Department of Neurobiology, Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China 2.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China 3.Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Nanjing Agricultural University, Nanj- ing, China |
| 推荐引用方式 GB/T 7714 | Bai HY,Cao J,Liu N,et al. Sexual Behavior Modulates Contextual Fear Memory Through Dopamine D1/D5 Receptors[J]. HIPPOCAMPUS,2009,19(3):289–298. |
| APA | Bai HY,Cao J,Liu N,Xu L,&Luo JH[*].(2009).Sexual Behavior Modulates Contextual Fear Memory Through Dopamine D1/D5 Receptors.HIPPOCAMPUS,19(3),289–298. |
| MLA | Bai HY,et al."Sexual Behavior Modulates Contextual Fear Memory Through Dopamine D1/D5 Receptors".HIPPOCAMPUS 19.3(2009):289–298. |
入库方式： OAI收割
来源：昆明动物研究所
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