Effects of prolonged exposure to context following contextual fear conditioning on synaptic properties in rat hippocampal slices
文献类型：期刊论文
| 作者 | Gao Y1; Han HL2,3; Xu L[*]2,4; Xu RC5; Cao J2; Luo JH[*]1 |
| 刊名 | NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 61期号:4页码:385-389 |
| 关键词 | stress context exposure long-term depression paired-pulse facilitation intervention |
| 通讯作者 | luojianhong@zju.edu.cn |
| 英文摘要 | Acute stressful events enhance plasma corticosterone release and profoundly affect synaptic functions, which are involved in the development of stress-related cognitive and mental disorders. However, how exposure to stressful context immediately after stress further modulates the physiological responses is not fully understood. Here, we found that acute stress inhibited paired-pulse facilitation in hippocampal slices of Wistar rats which were subjected to contextual fear conditioning. But such inhibition was reversed by subsequent prolonged exposure to foot-shock context or returning to home cage for I h. Interestingly, foot-shock stress-facilitated LTD induced by low frequency stimulation (LFS, 900 pulses at 1 Hz) was maintained by subsequent exposure to foot-shock context but was reversed by returning to home cage environment. Moreover, plasma corticosterone level was still kept higher in rats exposed to foot-shock context but not to home cage. Findings suggest that remaining in stressful environment immediately after stress maintains acute stress-facilitated LTD and higher level of neuroendocrine response. Our results also contribute to further understanding the critical role of timely intervention in mediating stress-related aversive changes in human. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Natural Science Foundation of China grants 30530250 and 30470549 (L.X.), National Basic Research Program 2006CB500800 (L.X.) and G2002CB713808 (J.H.L.) and an Outstanding Cross-Century FacultyGrant fromtheMinistryofEducationofChina(J.H.L.). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10860]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Department of Neurobiology, Institute for Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, PR China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, and Joint Centre for Bioresource and Common Disease Research, Kunming Institute of Zoology, Chinese Academy of Sciences/Faculty of Medicine, Chinese University of Hong Kong, Kunming 650223, PR China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China 4.Mental Health Institute, the 2nd Xiangya Hospital of Central South University, Changsha 410011, PR China 5.Second Affiliated Hospital Kunming Medical College, Kunming 650223, PR China |
| 推荐引用方式 GB/T 7714 | Gao Y,Han HL,Xu L[*],et al. Effects of prolonged exposure to context following contextual fear conditioning on synaptic properties in rat hippocampal slices[J]. NEUROSCIENCE RESEARCH,2008,61(4):385-389. |
| APA | Gao Y,Han HL,Xu L[*],Xu RC,Cao J,&Luo JH[*].(2008).Effects of prolonged exposure to context following contextual fear conditioning on synaptic properties in rat hippocampal slices.NEUROSCIENCE RESEARCH,61(4),385-389. |
| MLA | Gao Y,et al."Effects of prolonged exposure to context following contextual fear conditioning on synaptic properties in rat hippocampal slices".NEUROSCIENCE RESEARCH 61.4(2008):385-389. |
入库方式： OAI收割
来源：昆明动物研究所
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