Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio
文献类型：期刊论文
| 作者 | Dong ZF1,2; Zhong WX3; Cao J1,2; Sui N4; Xu TL5; Luo JH[*]3; Xu L[*]1,2,6; Tian M1,2; Han HL1,2; Mao RR1,2 |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 1207期号:X页码:164-173 |
| 关键词 | opiate withdrawal stress delayed-escape behaviour long-term potentiation NR2A NR2B hippocampus |
| 通讯作者 | lxu@vip.163.com ; luojianhong@zju.edu.cn |
| 英文摘要 | Repeated low-dose morphine treatment facilitates delayed-escape behaviour of hippocampus-dependent Morris water maze and morphine withdrawal influences hippocampal NMDA receptor-dependent synaptic plasticity. Here, we examined whether and how morphine withdrawal influenced delayed-escape behaviour and NR2A/2B expression ratio of hippocampal synaptosomes. We found that both delayed-escape behaviour and NR2A/2B expression ratio showed an inverted-U curve and peaked on 4-day withdrawal during a 20-day withdrawal period. Furthermore, treatment of the glucocorticoid receptor antagonist RU38486 for 3 days reduced delayed-escape behaviour and NR2A/2B ratio on 4-day withdrawal to a level similar to those of 18-h withdrawal. In contrast, elevated-platform stress enabled delayed-escape behaviour of 18-h withdrawal to a higher level similar to that of 4-day withdrawal, but had no significant effect on the NR2A/2B ratio. Similar behavioural effects were also found after intrahippocampal infusions of the NMDAR antagonist AP-5 or NR2B-containing NMDAR antagonist Ro25-6981 for 3 days. These findings suggest that delayed-escape behaviour enabled by repeated low-dose morphine treatment may be a useful and simple rat model for studying addictive memories to be retrieved by stress exposure. |
| 收录类别 | SCI |
| 资助信息 | This work is supported by grants from the National Natural Science Foundation of China (30530250 and 30470549 to L.X. and 30500150 to J.C.) and 973 program of the Ministry of Sci- ence and Technology of China (2006CB500808 to L.X., L.J.H., J.C. and 2007CB512303 to J.C.) and Science and Technology Foun- dation of Yunnan Province (2006PT08 to L.X.). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10862]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, PR China 2.Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, PR China 3.Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310006, PR China 4.Key Laboratory of Mental Health, Institute of Psychology, the Chinese Academy of Sciences, Beijing 100101, PR China 5.Institute of Neuroscience, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, PR China 6.Mental Health Institute, the 2nd Xiangya Hospital of Central South University, Changsha 410011, PR China |
| 推荐引用方式 GB/T 7714 | Dong ZF,Zhong WX,Cao J,et al. Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio[J]. BRAIN RESEARCH,2008,1207(X):164-173. |
| APA | Dong ZF.,Zhong WX.,Cao J.,Sui N.,Xu TL.,...&Mao RR.(2008).Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio.BRAIN RESEARCH,1207(X),164-173. |
| MLA | Dong ZF,et al."Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio".BRAIN RESEARCH 1207.X(2008):164-173. |
入库方式： OAI收割
来源：昆明动物研究所
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