Enriched environment treatment counteracts enhanced addictive and depressive-like behavior induced by prenatal chronic stress
文献类型：期刊论文
| 作者 | Yang JL1,2; Li WH1; Yang GF2; Lu X[*]1,3; Li LJ[*]1; Liu XH2; Li ZX1; Li HY1 |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2006 |
| 卷号 | 1125期号:X页码:132-137 |
| 关键词 | prenatal stress enriched environment onditioned place preference depressive-like behavior |
| 通讯作者 | lxu@vip.163.com ; 13807314575@hnmcc.com |
| 英文摘要 | Prenatal stress can cause many long-term behavior changes in offspring, but whether prenatal stress can alter addictive behavior in offspring and postnatal enriched environment treatment (EE) can restore these changes are unknown. We reported here that prenatal chronic stress (10 unpredictable, 1 s, 0.8 mA foot-shocks per day during gestational days 13-19) enhanced morphine-induced (10 mg/kg, s.c., per day, 6 consecutive days) place preference. Moreover, prenatal chronic stress caused higher depressive-like behavior in forced swimming test in adult offspring. However, enriched environment housing treatment on postnatal days 22-52 counteracted both the abnormal behaviors alterations. This work observed a phenomenon that might contribute to the understanding of clinically important interactions among addiction, prenatal stress and enriched environment treatment. Postnatal enriched environment treatment might be an important therapeutic intervention in preventing the prenatal stress-induced addictive disorders. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from National Science Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X.), and Basic Research 973 Program (2006CB500800 to L. X., L.J.L. and J.C.). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10873]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Mental Health Institute, The 2nd Xiangya Hospital, Central South University, Changsha 410011, PR China 2.Tianjin Anding Hospital, Tianjin 300074, PR China 3.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China |
| 推荐引用方式 GB/T 7714 | Yang JL,Li WH,Yang GF,et al. Enriched environment treatment counteracts enhanced addictive and depressive-like behavior induced by prenatal chronic stress[J]. BRAIN RESEARCH,2006,1125(X):132-137. |
| APA | Yang JL.,Li WH.,Yang GF.,Lu X[*].,Li LJ[*].,...&Li HY.(2006).Enriched environment treatment counteracts enhanced addictive and depressive-like behavior induced by prenatal chronic stress.BRAIN RESEARCH,1125(X),132-137. |
| MLA | Yang JL,et al."Enriched environment treatment counteracts enhanced addictive and depressive-like behavior induced by prenatal chronic stress".BRAIN RESEARCH 1125.X(2006):132-137. |
入库方式： OAI收割
来源：昆明动物研究所
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