NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo
文献类型：期刊论文
| 作者 | Wang MN1,2; Yang Y1,2; Dong ZF1,2; Cao J[*]1,2; Xu L[*]1,2,3 |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2006 |
| 卷号 | 17期号:12页码:1343-1346 |
| 关键词 | adult acute stress NR2B-containing N-methyl-D-aspartate subtype glutamate receptors anesthetized rats Ro25-6981 long-term potentiation long-term depression |
| 通讯作者 | juncao@vip.163.com ; lxu@vip.163.com |
| 英文摘要 | Behavioral stress facilitates long-term depression but impairs long-term potentiation in the hippocampus. Recent evidence in vitro demonstrates that the NIR2B-containing N-methyl-D-aspartate subtype glutamate receptor antagonist Ro25-6981 prevents the behavioral stress-facilitated hippocampal long-term depression. It is, however, unknown whether Ro25-6981 influences hippocampal long-term depression and long-term potentiation induction in vivo under stressful condition. Here, we found that infusion of Ro25-6981 (2.3 mu g in 6 mu l, intracerebroventricular for 10min) 30 min before low-frequency stimulation prevented the facilitation of hippocampal long-term depression by acute stress in anesthetized adult rats. Moreover, infusion of Ro25-6981 30min before high-frequency stimulation reversed stress-impaired hippocampal long-term potentiation. These results suggest that the NR2B-containing N-methyl-D-aspartate subtype glutamate receptors are crucial for the effects of behavioral stress on hippocampal long-term depression and long-term potentiation in vivo. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10875]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratoryof Animal Models and HumanDiseaseMechanisms, and Laboratoryof Learning and Memory,Kunming Institute of Zoology, the Chinese AcademyofSciences,Kunming 2.Graduate Schoolof the ChineseAcademyofSciences, Beijing 3.Mental Health Institute, the 2nd Xiangya Hospitalof Central South University,Changsha,Hunan,PRChina |
| 推荐引用方式 GB/T 7714 | Wang MN,Yang Y,Dong ZF,et al. NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo[J]. NEUROREPORT,2006,17(12):1343-1346. |
| APA | Wang MN,Yang Y,Dong ZF,Cao J[*],&Xu L[*].(2006).NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo.NEUROREPORT,17(12),1343-1346. |
| MLA | Wang MN,et al."NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo".NEUROREPORT 17.12(2006):1343-1346. |
入库方式： OAI收割
来源：昆明动物研究所
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