Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress
文献类型：期刊论文
| 作者 | Cui MH1; Yang Y1,2; Ma WP2,3,4; Li HB2,3; Mao RR2,3; Xu L1,2,3; Hao W[*]1; Cao J[*]2,3; Yang JL1; Zhang JC2,3 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2006 |
| 卷号 | 404期号:1-2页码:208-212 |
| 关键词 | enriched environment memory long-term potentiation hippocampus forced swim stress Morris water maze |
| 通讯作者 | weihao57@china.com ; juncao@vip.163.com |
| 英文摘要 | Stress in early life is believed to cause cognitive and affective disorders, and to disrupt hippocampal synaptic plasticity in adolescence into adult, but it is unclear whether exposure to enriched environment (EE) can overcome these effects. Here, we reported that housing rats in cages with limited nesting/bedding materials on postnatal days 2-21 reduced body weight gain, and this type of early life stress impaired spatial learning and memory of the Morris water maze and increased depressive-like behavior of the forced swim test in young adult rats (postnatal days 53-57). Early life stress also impaired long-term potentiation in hippocampal CA I area of slices of young adult rats. Remarkably, EE experience on postnatal days 22-52 had no effect on spatial learning/memory and depressive-like behavior, but it significantly facilitated UP in control rats, and completely overcame the effects of early life stress on young adult rats. These findings suggest that EE experience may be useful for clinical intervention in preventing cognitive and affective disorders during development. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from National Science Foundation of China (t30370522 to W.H.) and Basic Research 973 Program (2003CB515404 to W.H.). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10876]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Mental Health Institute and WHO Collaborating Center for Psychosocial Factors, Drug Abuse and Health, the 2nd Hospital of Central South University, Changsha 410011, PR China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, PR China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China 4.Department of Physiology, Kunming Medical College, Kunming 650031, PR China |
| 推荐引用方式 GB/T 7714 | Cui MH,Yang Y,Ma WP,et al. Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress[J]. NEUROSCIENCE LETTERS,2006,404(1-2):208-212. |
| APA | Cui MH.,Yang Y.,Ma WP.,Li HB.,Mao RR.,...&Han HL.(2006).Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress.NEUROSCIENCE LETTERS,404(1-2),208-212. |
| MLA | Cui MH,et al."Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress".NEUROSCIENCE LETTERS 404.1-2(2006):208-212. |
入库方式： OAI收割
来源：昆明动物研究所
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