Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring
文献类型：期刊论文
| 作者 | Yang JL1; Han HL2,3; Cao J[*]2,3; Li LJ[*]1; Xu L[*]1,2,3 |
| 刊名 | HIPPOCAMPUS
 |
| 出版日期 | 2006 |
| 卷号 | 16期号:5页码:431-436 |
| 关键词 | prenatal stress long-term potentiation long-term depression hippocampal CA1 memory Morris water maze |
| 通讯作者 | juncao@vip.163.com ; 13807314575@hnmcc.com ; lxu@vip.163.com |
| 英文摘要 | Clinical studies demonstrate that prenatal stress causes cognitive deficits and increases vulnerability to affective disorders in children and adolescents. The underlying mechanisms are not yet fully understood. Here, we reported that prenatal stress (10 unpredictable, 1 s, 0.8 mA foot shocks per day during gestational days 13-19) impaired long-term potentiation (LTP) but facilitated long-term depression (LTD) in hippocampal CA1 region in slices of the prenatal stressed offspring (5 weeks old). Cross-fostering neonate offspring by the prenatal stressed or control mothers did not change the effects of prenatal stress on the hippocampal LTP and LTD. Furthermore, prenatal stress enhanced the effects of acute stress on the hippocampal LTP and LTD and impaired spatial learning and memory in the Morris water maze in the young rat offspring. Therefore, prenatal stress alters synaptic plasticity and enhances the effects of acute stress on synaptic plasticity in the hippocampus, which may be the mechanism for the impaired spatial learning and memory in young rat offspring. |
| 收录类别 | SCI |
| 资助信息 | The National Science Foundation of China; Grant numbers: 30170342, 30470621, 30530250, 30470549; Grant sponsor: The Department of Science and Technology of China; Grant number: 2006CB500800. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10883]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Mental Health Institute, The 2nd Xiangya Hospital of Central South University, Changsha 410011, Hunan, People’s Republic of China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, and Lab- oratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, Yunnan, People’s Republic of China 3.Graduate School of the Chinese Academy of Scien- ces, Beijing100039, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Yang JL,Han HL,Cao J[*],et al. Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring[J]. HIPPOCAMPUS,2006,16(5):431-436. |
| APA | Yang JL,Han HL,Cao J[*],Li LJ[*],&Xu L[*].(2006).Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring.HIPPOCAMPUS,16(5),431-436. |
| MLA | Yang JL,et al."Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring".HIPPOCAMPUS 16.5(2006):431-436. |
入库方式： OAI收割
来源：昆明动物研究所
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