Morphine conditioned place preference depends on glucocorticoid receptors in both hippocampus and nucleus accumbens
文献类型：期刊论文
| 作者 | Dong ZF1,2,3; Han HL1,2,3; Cao J[*]1,2,3; Wang MN1,2,3; Xu L1,2,3,4; Hao W[*]4,5 |
| 刊名 | HIPPOCAMPUS
 |
| 出版日期 | 2006 |
| 卷号 | 16期号:10页码:809-813 |
| 关键词 | morphine conditioned place preference drug-associated learning hippocampus glucocorticoid receptors |
| 通讯作者 | weihao57@china.com ; juncao@vip.163.com |
| 英文摘要 | Learned association between drugs of abuse and context is essential for the formation of drug conditioned place preference (CPP), which is believed to engage many brain regions including hippocampus, and nucleus accumbens (NAc). The underlying mechanisms are not fully understood. Here, we examined whether glucocorticoid receptors (GRs) of hippocampus and NAc influenced the formation of morphine CPP in Sprague Dawley rats. We found that systemic or intrahippocampal infused DMSO vehicle (DMSO 20% in saline) 30 min before daily morphine (10 mg/kg, sc) conditioning did not affect the formation of morphine CPP. In contrast, systemic administration (5 mg/kg, sc) or intrahippocampal infusion (0, 0.1, 1.0, 10, 20 mu g per side) of the GR antagonist RU38486 blocked or impaired the formation of CPP in a dose-dependent manner, respectively. Furthermore, intra-NAc infused RU38486 (10 mu g per side) but not DMSO vehicle also prevented the formation of CPP. These results demonstrate that both the GRs of hippocampus and NAc are necessary for the formation of morphine CPP, suggesting a neural network function of the GRs in forming the opiate-associated memory. |
| 收录类别 | SCI |
| 资助信息 | National Science Foundation of China; Grant numbers: 30500150, 30530250, 30470549, 30370522; Grant sponsor: Basic Research Program of China (973 program), Ministry of Science and Technology. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10884]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, t 2.Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kun- ming, Yunnan, People’s Republic of China 3.Graduate School of the Chi- nese Academy of Sciences, Beijing, People’s Republic of China 4.Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, People’s Republic of China 5.WHO Collaborating Center for Psychosocial Factors, Drug Abuse and Health, Changsha, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Dong ZF,Han HL,Cao J[*],et al. Morphine conditioned place preference depends on glucocorticoid receptors in both hippocampus and nucleus accumbens[J]. HIPPOCAMPUS,2006,16(10):809-813. |
| APA | Dong ZF,Han HL,Cao J[*],Wang MN,Xu L,&Hao W[*].(2006).Morphine conditioned place preference depends on glucocorticoid receptors in both hippocampus and nucleus accumbens.HIPPOCAMPUS,16(10),809-813. |
| MLA | Dong ZF,et al."Morphine conditioned place preference depends on glucocorticoid receptors in both hippocampus and nucleus accumbens".HIPPOCAMPUS 16.10(2006):809-813. |
入库方式： OAI收割
来源：昆明动物研究所
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