Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term depression in the CA1 region of the hippocampal slice
文献类型：期刊论文
| 作者 | Zhang JC1; Yang Y1; Li HB1; Cao J[*]1; Xu L[*]1,2 |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 1050期号:1-2页码:110-117 |
| 关键词 | synaptic plasticity long-term depression long-term potentiation miniature EPSC hippocampus metaplasticity |
| 通讯作者 | juncao@vip.163.com ; lxu@vip.163.com |
| 英文摘要 | Prior synaptic or cellular activity influences degree or threshold for subsequent induction of synaptic plasticity, a process known as metaplasticity. Thus, the continual synaptic activity, spontaneous miniature excitatory synaptic current (mEPSC) may correlate to the induction of long-teen depression (LTD). Here, we recorded whole-cell EPSC and mEPSC alternately in the Schaffer-CA1 synapses in brain slice of young rats, and found that this recording configuration affected neither EPSC nor mEPSC. Low frequency stimulation (LFS) induced variable magnitudes of LTD. Remarkably, larger magnitudes of LTD were significantly correlated to smaller amplitude/lower frequency of the basal mEPSC. Furthermore, under the conditions reduced amplitude/frequency of the basal mEPSC by exposure to behavioral stress immediately before slice preparation or low concentration of calcium in bath solution, the magnitudes of LTD were still inversely correlated to mEPSC amplitude/frequency. These new findings suggest that spontaneous mEPSC may reflect functional and/or structural aspects of the synapses, the synaptic history ongoing metaplasticity. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the Chinese Academy of Sciences (KSCX2-SW-04) and the National Science Foundation of China (30470549) to L.X. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10888]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223 and Graduate School of The Chinese Academy of Sciences, Beijing 100039, PR China 2.Mental Health Institute of the 2nd Hospital of Xiangya Medical College, Central South University, Changsha 410011, PR China |
| 推荐引用方式 GB/T 7714 | Zhang JC,Yang Y,Li HB,et al. Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term depression in the CA1 region of the hippocampal slice[J]. BRAIN RESEARCH,2005,1050(1-2):110-117. |
| APA | Zhang JC,Yang Y,Li HB,Cao J[*],&Xu L[*].(2005).Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term depression in the CA1 region of the hippocampal slice.BRAIN RESEARCH,1050(1-2),110-117. |
| MLA | Zhang JC,et al."Amplitude/frequency of spontaneous mEPSC correlates to the degree of long-term depression in the CA1 region of the hippocampal slice".BRAIN RESEARCH 1050.1-2(2005):110-117. |
入库方式： OAI收割
来源：昆明动物研究所
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