Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors
文献类型：期刊论文
| 作者 | Li HB1,2; Zhang JC1,2; Xu L[*]1,2,4; Xiong WY1,2; Xu TL3; Cao J[*]1,2 |
| 刊名 | NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 52期号:3页码:287-294 |
| 关键词 | long-term depression (LTD) subiculum muscarinic receptor G-protein calcium |
| 通讯作者 | juncao@vip.163.com ; lxu@vip.163.com |
| 英文摘要 | The subiculum, which is the primary target of CA1 pyramidal neurons and sending efferent fibres to many brain regions, serves as a hippocampal interface in the neural information processes between hippocampal formation and neocortex. Long-term depression (LTD) is extensively studied in the hippocampus, but not at the CA1-subicular synaptic transmission. Using whole-cell EPSC recordings in the brain slices of young rats, we demonstrated that the pairing protocols of low frequency stimulation (LFS) at 3 Hz and postsynaptic depolarization of -50 mVelicited a reliable LTD in the subiculum. The LTD did not cause the changes of the paired-pulse ratio of EPSC. Furthermore, it did not depend on either NMDA receptors or voltage-gated calcium channels (VGCCs). Bath application of the G-protein coupled muscarinic acetylcholine receptors (mAChRs) antagonists, atropine or scopolamine, blocked the LTD, suggesting that mAChRs are involved in the LTD. It was also completely blocked by either the Ca2+ chelator BAPTA or the G-protein inhibitor GDP-beta-S in the intracellular solution. This type of LTD in the subiculum may play a particular role in the neural information processing between the hippocampus and neocortex. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from The Chinese Academy of Sciences (KSCX2-SW-04) and The National Science Foundation of China (30470549) to L. X. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10889]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China 3.Institute of Neuroscience, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, PR China 4.Mental Health Institute of the 2nd Xiangya Hospital, Central South University, Changsha 410011, PR China |
| 推荐引用方式 GB/T 7714 | Li HB,Zhang JC,Xu L[*],et al. Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors[J]. NEUROSCIENCE RESEARCH,2005,52(3):287-294. |
| APA | Li HB,Zhang JC,Xu L[*],Xiong WY,Xu TL,&Cao J[*].(2005).Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors.NEUROSCIENCE RESEARCH,52(3),287-294. |
| MLA | Li HB,et al."Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors".NEUROSCIENCE RESEARCH 52.3(2005):287-294. |
入库方式： OAI收割
来源：昆明动物研究所
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