Propofol effects on excitatory synaptic efficacy in the CA1 region of the developing hippocarnpus
文献类型：期刊论文
| 作者 | Sun XH1; Zhang JC2; Cui MH4; Zeng BX1; Xu TL3; Cao J[*]2; Xu L[*]2,4; Li HB2; Zhang Z3; Yang JL4 |
| 刊名 | DEVELOPMENTAL BRAIN RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 157期号:1页码:1-7 |
| 关键词 | propofol EPSC long-term depression hippocampus development |
| 通讯作者 | juncao@vip.163.com ; lxu@vip.163.com |
| 英文摘要 | The anesthetic, propofol, effectively suppresses excitatory synaptic transmission and facilitates long-term depression (LTD) in the CA1 region of the hippocampus. Here, we have examined whether these effects are different in the developing hippocampus. We found that propofol in suppressing whole-cell excitatory postsynaptic currents (EPSC) was more effective in 21 day old rats than either in 7 day old rats or under the condition of high intracellular chloride concentration in 21 day old rats. Furthermore, the propofol concentration to facilitate the NMDA receptor-dependent LTD was lower at postnatal day 21 than at postnatal day 7. Interestingly, the decay time of EPSC was decreased during the development from postnatal day 7 to 21, but it was increased by the recording condition of high intracellular chloride concentration or by propofol administration. All these effects of propofol were dependent on the chloride channel opening. These observations suggest that propofol may induce differential anesthetic effects in the developing hippocampus, at least partially, depending on the intracellular chloride concentration. |
| 收录类别 | SCI |
| 资助信息 | The grants from Chinese Academy of Sciences (KSCX2- SW-04) and National Science Foundation (30470549) to L.X. supported this work. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10890]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Anaesthesiological Section, Union Hospital affiliated to TongJi Medical College, Huazhong University of Technology, Wuhan 430074, PR China 2.Laboraotory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China 3.School of Life Sciences, University of Science and Technology of China, Hefei 230027 and Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 20003, PR China 4.Mental Health Institute, The 2nd Hospital of XiangYa Medical College, Central South University, Changsha 410011, PR China |
| 推荐引用方式 GB/T 7714 | Sun XH,Zhang JC,Cui MH,et al. Propofol effects on excitatory synaptic efficacy in the CA1 region of the developing hippocarnpus[J]. DEVELOPMENTAL BRAIN RESEARCH,2005,157(1):1-7. |
| APA | Sun XH.,Zhang JC.,Cui MH.,Zeng BX.,Xu TL.,...&Yang JL.(2005).Propofol effects on excitatory synaptic efficacy in the CA1 region of the developing hippocarnpus.DEVELOPMENTAL BRAIN RESEARCH,157(1),1-7. |
| MLA | Sun XH,et al."Propofol effects on excitatory synaptic efficacy in the CA1 region of the developing hippocarnpus".DEVELOPMENTAL BRAIN RESEARCH 157.1(2005):1-7. |
入库方式： OAI收割
来源：昆明动物研究所
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