Effects of unconditioned and conditioned aversive stimuli in an intense fear conditioning paradigm on synaptic plasticity in the hippocampal CA1 area in vivo
文献类型：期刊论文
| 作者 | Li ZX1; Zhou QX2,3; Peng WH2,3; Dong ZF2,3; Xu L1,2; Cao J[*]2; Li LJ[*]1; Mao RR2,3; Wang MN2,3 |
| 刊名 | HIPPOCAMPUS
 |
| 出版日期 | 2005 |
| 卷号 | 15期号:6页码:815-824 |
| 关键词 | long-term potentiation long-term depression post-traumatic stress disorder stress hippocampus-dependent memory |
| 通讯作者 | juncao@vip.163.com |
| 英文摘要 | Repeated vivid recalls or flashbacks of traumatic memories and memory deficits are the cardinal features of post-traumatic stress disorder (PTSD). The underlying mechanisms are not fully understood yet. Here, we examined the effects of very strong fear conditioning (20 pairings of a light with a 1.5-mA, 0.5-s foot shock) and subsequent reexposure to the conditioning context (chamber A), a similar context (chamber B), and/or to the fear conditioned stimulus (CS) (a light) on synaptic plasticity in the hippocampal CA1 area in anesthetized Sprague-Dawley rats. The conditioning procedure resulted in very strong conditioned fear, as reflected by high levels of persistent freezing, to both the contexts and to the CS, 24 h after fear conditioning. The induction of long-term potentiation ON was blocked immediately after fear conditioning. It was still markedly impaired 24 h after fear conditioning; reexposure to the conditioning chamber A (CA) or to a similar chamber 13 (CB) did not affect the impairment. However, presentation of the CS in the CA exacerbated the impairment of LTP, whereas the CS presentation in a CB ameliorated the impairment so that LTP induction did not differ from that of control groups. The induction of long-term depression (LTD) was facilitated immediately, but not 24 h, after fear conditioning. Only reexposure to the CS in the CA, but not reexposure to either chamber A or B alone, or the CS in chamber B, 24 h after conditioning, reinstated the facilitation of LTD induction. These data demonstrate that unconditioned and conditioned aversive stimuli in an intense fear conditioning paradigm can have profound effects on hippocampal synaptic plasticity, which may aid to understand the mechanisms underlying impairments of hippocampus-dependent memory by stress or in PTSD. |
| 收录类别 | SCI |
| 资助信息 | The National Natural Science Foundation of China; Grant numbers: 30170342 and 30470549; Grant sponsor: The Chinese Academy of Sciences; Grant number: KSCX2-SW-04; Grant sponsor: National Basic Research Program of China; Grant number: 2006CB500808. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10892]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Mental Health Institute of the 2nd Xiangya Hospital, Central South University, Changsha 410011, Hunan, People’s Republic of China 2.Lab- oratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, Yunnan, People’s Republic of China 3.Graduate School of the Chinese Academy of Scien- ces, Beijing 100039, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Li ZX,Zhou QX,Peng WH,et al. Effects of unconditioned and conditioned aversive stimuli in an intense fear conditioning paradigm on synaptic plasticity in the hippocampal CA1 area in vivo[J]. HIPPOCAMPUS,2005,15(6):815-824. |
| APA | Li ZX.,Zhou QX.,Peng WH.,Dong ZF.,Xu L.,...&Wang MN.(2005).Effects of unconditioned and conditioned aversive stimuli in an intense fear conditioning paradigm on synaptic plasticity in the hippocampal CA1 area in vivo.HIPPOCAMPUS,15(6),815-824. |
| MLA | Li ZX,et al."Effects of unconditioned and conditioned aversive stimuli in an intense fear conditioning paradigm on synaptic plasticity in the hippocampal CA1 area in vivo".HIPPOCAMPUS 15.6(2005):815-824. |
入库方式： OAI收割
来源：昆明动物研究所
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