Identification of a Giardia krr1 homolog gene and the secondarily anucleolate condition of Giaridia lamblia
文献类型：期刊论文
| 作者 | Xin DD1,2; Wen JF1; He D1,2; Lu SQ3 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2005 |
| 卷号 | 22期号:3页码:391-394 |
| 关键词 | Giardia lamblia krr1 gene nucleolus rRNA-processing evolution |
| ISSN号 | 0737-4038 |
| 通讯作者 | wenjf@mail.kiz.ac.cn |
| 英文摘要 | Giaridia lamblia was long considered to be one of the most primitive eukaryotes and to lie close to the transition between prokaryotes and eukaryotes, but several supporting features, such as lack of mitochondrion and Golgi, have been challenged recently. It was also reported previously that G. lamblia lacked nucleolus, which is the site of pre-rRNA processing and ribosomal assembling in the other eukaryotic cells. Here, we report the identification of the yeast homolog gene, krr1, in the anucleolate eukaryote, G. lamblia. The krr1 gene, encoding one of the pre-rRNA processing proteins in yeast, is actively transcribed in G. lamblia. The deduced protein sequence of G. lamblia krr1 is highly similar to yeast KRR1p that contains a single-KH domain. Our database searches indicated that krr1 genes actually present in diverse eukaryotes and also seem to present in Archaea. However, only the eukaryotic homologs, including that of G. lamblia, have the single-KH domain, which contains the conserved motif KR(K)R. Fibrillarin, another important pre-rRNA processing protein has also been identified previously in G. lamblia. Moreover, our database search shows that nearly half of the other nucleolus-localized protein genes of eukaryotic cells also have their homologs in Giardia. Therefore, we suggest that a common mechanism of pre-RNA processing may operate in the anucleolate eukaryote G. lamblia and in the other eukaryotes and that like the case of "lack of mitochondrion," "lack of nucleolus" may not be a primitive feature, but a secondarily evolutionary condition of the parasite. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants (30070362, 30170135, 30021004) from the National Natural Science Foundation of China to J.F.W and a grant (KSCX2-SW-101C) from the Chinese Academy of Sci- ences to J.F.W. |
| 原文出处 | 200522391.pdf |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5963]  |
| 专题 | 昆明动物研究所_真核细胞进化基因组 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Graduate School of the Chinese Academy of Sciences, Beijing, China 3.Capital University of Medical Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Xin DD,Wen JF,He D,et al. Identification of a Giardia krr1 homolog gene and the secondarily anucleolate condition of Giaridia lamblia[J]. MOLECULAR BIOLOGY AND EVOLUTION,2005,22(3):391-394. |
| APA | Xin DD,Wen JF,He D,&Lu SQ.(2005).Identification of a Giardia krr1 homolog gene and the secondarily anucleolate condition of Giaridia lamblia.MOLECULAR BIOLOGY AND EVOLUTION,22(3),391-394. |
| MLA | Xin DD,et al."Identification of a Giardia krr1 homolog gene and the secondarily anucleolate condition of Giaridia lamblia".MOLECULAR BIOLOGY AND EVOLUTION 22.3(2005):391-394. |
入库方式： OAI收割
来源：昆明动物研究所
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