Origin and Evolution of the Eukaryotic SSU Processome Revealed by a Comprehensive Genomic Analysis and Implications for the Origin of the Nucleolus
文献类型：期刊论文
| 作者 | Feng JM; Tian HF; Wen JF[*] |
| 刊名 | GENOME BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:12页码:2255-2267 |
| 关键词 | SSU processome evolution nucleolus LECA origin |
| 通讯作者 | wenjf@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | As a nucleolar complex for small-subunit (SSU) ribosomal RNA processing, SSU processome has been extensively studied mainly in Saccharomyces cerevisiae but not in diverse organisms, leaving open the question of whether it is a ubiquitous mechanism across eukaryotes and how it evolved in the course of the evolution of eukaryotes. Genome-wide survey and identification of SSU processome components showed that the majority of all 77 yeast SSU processome proteins possess homologs in almost all of the main eukaryotic lineages, and 14 of them have homologs in archaea but few in bacteria, suggesting that the complex is ubiquitous in eukaryotes, and its evolutionary history began with abundant protein homologs being present in archaea and then a fairly complete form of the complex emerged in the last eukaryotic common ancestor (LECA). Phylogenetic analysis indicated that ancient gene duplication and functional divergence of the protein components of the complex occurred frequently during the evolutionary origin of the LECA from prokaryotes. We found that such duplications not only increased the complex's components but also produced some new functional proteins involved in other nucleolar functions, such as ribosome biogenesis and even some nonnucleolar (but nuclear) proteins participating in pre-mRNA splicing, implying the evolutionary emergence of the subnuclear compartment-the nucleolus-has occurred in the LECA. Therefore, the LECA harbored not only complicated SSU processomes but also a nucleolus. Our analysis also revealed that gene duplication, innovation, and loss, caused further divergence of the complex during the divergence of eukaryotes. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (30830018, 31172081, 31123005), the Knowledge Innovation Program (KSCX2- EW-J-23) from the Chinese Academy of Sciences, the 973 Program (2007CB815705), and the grant (2008GA002) from Yunnan province to J.F. |
| 语种 | 英语 |
| WOS记录号 | WOS:000329250400001 |
| 公开日期 | 2014-01-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7790]  |
| 专题 | 昆明动物研究所_真核细胞进化基因组 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Feng JM,Tian HF,Wen JF[*]. Origin and Evolution of the Eukaryotic SSU Processome Revealed by a Comprehensive Genomic Analysis and Implications for the Origin of the Nucleolus[J]. GENOME BIOLOGY AND EVOLUTION,2013,5(12):2255-2267. |
| APA | Feng JM,Tian HF,&Wen JF[*].(2013).Origin and Evolution of the Eukaryotic SSU Processome Revealed by a Comprehensive Genomic Analysis and Implications for the Origin of the Nucleolus.GENOME BIOLOGY AND EVOLUTION,5(12),2255-2267. |
| MLA | Feng JM,et al."Origin and Evolution of the Eukaryotic SSU Processome Revealed by a Comprehensive Genomic Analysis and Implications for the Origin of the Nucleolus".GENOME BIOLOGY AND EVOLUTION 5.12(2013):2255-2267. |
入库方式： OAI收割
来源：昆明动物研究所
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