Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis)
文献类型：期刊论文
| 作者 | Li RX1; Xu W1; Zeng R[*]1; Wang Z1; Liang B2; Wu JR1 |
| 刊名 | PROTEIN & CELL
 |
| 出版日期 | 2012 |
| 卷号 | 3期号:9页码:691-700 |
| 关键词 | proteome Chinese tree shrew phylogenetic tree liver muscle |
| 通讯作者 | zr@sibs.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Valid animal models are useful for studying the pathophysiology of specific disorders, such as neural disease, diabetes and cancer. Previous molecular phylogeny studies indicate that the tree shrew is in the same order as (or a close sister to) primates, and thus may be an ideal model in which to study human disease. In this study, the proteome of liver and muscle tissue in tree the shrew was identified by combining peptide fractionation and LC-MS/MS identification. In total, 2146 proteins were detected, including 1759 proteins in liver samples and 885 proteins in skeletal muscle samples from the tree shrew. Further sub-source analysis revealed that nearly half of the identified proteins (846 proteins and 418 proteins) were derived from human database. In this study, we are the first to describe the characteristics of the proteome from the liver and skeletal muscle of the tree shrew. Phylogenetic tree analysis based on these proteomic data showed that the tree shrew is closer to primates (human) than to glires (the mouse and rat). |
| 收录类别 | SCI |
| 资助信息 | This project was supported by the grants from the Knowledge Inno- vation Program of the Chinese Academy of Sciences (No. KSCX2- EW-R-12) and grants from National Natural Science Foundation Youth Fund of China (Grant No. 30900261). The Author Gratefully Acknowledges the Support of SA-SIBS Scholarship Program. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10379]  |
| 专题 | 昆明动物研究所_脂类代谢与疾病 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai 200031, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Li RX,Xu W,Zeng R[*],et al. Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis)[J]. PROTEIN & CELL,2012,3(9):691-700. |
| APA | Li RX,Xu W,Zeng R[*],Wang Z,Liang B,&Wu JR.(2012).Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis).PROTEIN & CELL,3(9),691-700. |
| MLA | Li RX,et al."Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis)".PROTEIN & CELL 3.9(2012):691-700. |
入库方式： OAI收割
来源：昆明动物研究所
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